Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation. - Wikidata - wikimedia - TriplyDB

Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation.

Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation.

http://www.wikidata.org/entity/Q41484948

about

Echoes of the embryo: using the developmental biology toolkit to study cancer Stem cells in genetically-engineered mouse models of prostate cancer The many ways to make a luminal cell and a prostate cancer cell Roles for Hedgehog signaling in adult organ homeostasis and repair Biologic and clinical significance of androgen receptor variants in castration resistant prostate cancer Notch signaling in prostate cancer: a moving target Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells Bidirectional interconversion of stem and non-stem cancer cell populations: A reassessment of theoretical models for tumor heterogeneity Cell-of-Origin of Cancer versus Cancer Stem Cells: Assays and Interpretations Organoid development in cancer genome discovery Loss of survivin in the prostate epithelium impedes carcinogenesis in a mouse model of prostate adenocarcinoma Sonic hedgehog signals to multiple prostate stromal stem cells that replenish distinct stromal subtypes during regeneration.Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth.Transient induction of ING4 by Myc drives prostate epithelial cell differentiation and its disruption drives prostate tumorigenesis.Mouse models of prostate cancer: picking the best model for the question.The prostate basal cell (BC) heterogeneity and the p63-positive BC differentiation spectrum in mice.Luminal cells are favored as the cell of origin for prostate cancer Single luminal epithelial progenitors can generate prostate organoids in culture.Estrogen receptor β activation impairs prostatic regeneration by inducing apoptosis in murine and human stem/progenitor enriched cell populations.Molecular pathways and targets in prostate cancer Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells Prostate epithelial stem and progenitor cells.Klf5 deletion promotes Pten deletion-initiated luminal-type mouse prostate tumors through multiple oncogenic signaling pathways Human prostate side population cells demonstrate stem cell properties in recombination with urogenital sinus mesenchyme.Induced pluripotency of human prostatic epithelial cells.Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas.Hedgehog signaling in prostate epithelial-mesenchymal growth regulation.Enhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules Differential gene expression profiling of functionally and developmentally distinct human prostate epithelial populations Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.Cell kinetic studies fail to identify sequentially proliferating progenitors as the major source of epithelial renewal in the adult murine prostate.Pten Regulates Epithelial Cytodifferentiation during Prostate Development.Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment.Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment.Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors.PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland β4 Integrin signaling induces expansion of prostate tumor progenitors

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P2860

Adult murine prostate basal and luminal cells are self-sustained lineages that can both serve as targets for prostate cancer initiation.

http://www.wikidata.org/entity/Q41484948

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Adult murine prostate basal an ...... or prostate cancer initiation.

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Boyu Zhang

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Li Xin

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Li Zhang

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Michael Ittmann

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Nahyun Choi

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P2860

Identification of a cell of origin for human prostate cancer

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Expressed sequence tag profiling identifies developmental and anatomic partitioning of gene expression in the mouse prostate

Generation of a prostate from a single adult stem cell

Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor

Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

A global double-fluorescent Cre reporter mouse

Cells of origin in cancer

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

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