The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.
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Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECKMatriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivityInhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulinThe c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspasesHuman alpha2-macroglobulin is composed of multiple domains, as predicted by homology with complement component C3Alpha-2-macroglobulin functions as an inhibitor of fibrinolytic, clotting, and neutrophilic proteinases in sepsis: studies using a baboon modelMethionine oxidation and reduction in proteinsDiagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver diseaseThe crystal structure of human α2-macroglobulin reveals a unique molecular cageActivated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone proteinBinding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interactionHydrolysis of the elastase substrate succinyltrialanine nitroanilide by a metal-dependent enzyme in rheumatoid synovial fluidEvolution of alpha 2-macroglobulin. The demonstration in a variety of vertebrate species of a protein resembling human alpha 2-macroglobulinA 16-amino acid peptide from human alpha2-macroglobulin binds transforming growth factor-beta and platelet-derived growth factor-BB.Distinct binding sites in the structure of alpha 2-macroglobulin mediate the interaction with beta-amyloid peptide and growth factors.Binding of transforming growth factor-beta 1 to methylamine-modified alpha 2-macroglobulin and to binary and ternary alpha 2-macroglobulin-proteinase complexesBeta-amyloid peptide binds equivalently to binary and ternary alpha2-macroglobulin-protease complexes.Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain.The structure of alpha 2-macroglobulin-methylamine after papain digestion as determined by electron microscopy.Binding of tumor necrosis factor alpha to activated forms of human plasma alpha 2 macroglobulinImaging biological structures with the cryo atomic force microscope.An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in miceAlpha 2-macroglobulin is the primary inhibitor of miniplasmin in vitro and in vivo in the mouse. Comparison with alpha 2-antiplasmin in simultaneous reaction experiments.Kinetics of the reaction of streptokinase-plasmin complex with purified human and mouse alpha 2-macroglobulin. Implications for mechanism.Alpha 2-macroglobulin functions as a cytokine carrier to induce nitric oxide synthesis and cause nitric oxide-dependent cytotoxicity in the RAW 264.7 macrophage cell line.Binding of platelet-derived growth factor-BB and transforming growth factor-beta 1 to alpha 2-macroglobulin in vitro and in vivo: comparison of receptor-recognized and non-recognized alpha 2-macroglobulin conformations.Differences in the binding of transforming growth factor beta 1 to the acute-phase reactant and constitutively synthesized alpha-macroglobulins of rat.Murine alpha-macroglobulins demonstrate divergent activities as neutralizers of transforming growth factor-beta and as inducers of nitric oxide synthesis. A possible mechanism for the endotoxin insensitivity of the alpha2-macroglobulin gene knock-ouProteinases are isoform-specific regulators of the binding of transforming growth factor beta to alpha 2-macroglobulin.alpha 2-Macroglobulin synthesis by the human monocytic cell line THP-1 is differentiation state-dependent.Localization of the binding site for transforming growth factor-beta in human alpha2-macroglobulin to a 20-kDa peptide that also contains the bait region.alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis.alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers.Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease.Serum matrix metalloproteinase-2 levels indicate blood-CSF barrier damage in patients with infectious meningitis.Fetuin: its enigmatic property of growth promotion.alpha-Macroglobulins are present in some gram-negative bacteria: characterization of the alpha2-macroglobulin from Escherichia coli.Snake venom hemorrhagins.Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory.Structure of native alpha 2-macroglobulin and its transformation to the protease bound form
P2860
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P2860
The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.
description
1973 nî lūn-bûn
@nan
1973年の論文
@ja
1973年論文
@yue
1973年論文
@zh-hant
1973年論文
@zh-hk
1973年論文
@zh-mo
1973年論文
@zh-tw
1973年论文
@wuu
1973年论文
@zh
1973年论文
@zh-cn
name
The interaction of alpha 2-mac ...... rning its molecular mechanism.
@en
type
label
The interaction of alpha 2-mac ...... rning its molecular mechanism.
@en
prefLabel
The interaction of alpha 2-mac ...... rning its molecular mechanism.
@en
P2860
P356
P1433
P1476
The interaction of alpha 2-mac ...... rning its molecular mechanism.
@en
P2093
Barrett AJ
Starkey PM
P2860
P304
P356
10.1042/BJ1330709
P407
P577
1973-08-01T00:00:00Z