The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.
about
Localization of an integrin binding site to the C terminus of talin.Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinityTyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.Studies of activated GPIIb/IIIa receptors on the luminal surface of adherent platelets. Paradoxical loss of luminal receptors when platelets adhere to high density fibrinogenDisrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.A few immobilized thrombins are sufficient for platelet spreadingGlycoprotein IIb-IIIa and the translocation of Rap2B to the platelet cytoskeleton.Bound fibrinogen distribution on stimulated platelets. Examination by confocal scanning laser microscopyFibrinogen and glycoprotein IIb/IIIa localization during platelet adhesion. Localization to the granulomere and at sites of platelet interaction.Platelet morphologic changes and fibrinogen receptor localization. Initial responses in ADP-activated human platelets.Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets.Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.Immunoelectron microscopic localization of type 1 plasminogen activator inhibitor on the surface of activated endothelial cells.Redistribution of GPIb/IX and GPIIb/IIIa during spreading of discoid platelets.Defining extracellular integrin alpha-chain sites that affect cell adhesion and adhesion strengthening without altering soluble ligand bindingExpression of alpha v and beta 3 integrin chains on murine lymphocytes.Adhesive interactions of platelets and their blockade.Current concepts of platelet activation: possibilities for therapeutic modulation of heterotypic vs. homotypic aggregation.RGDfK-functionalized gold nanorods bind only to activated platelets.Dynamic measurements of the platelet membrane glycoprotein IIb-IIIa receptor for fibrinogen by flow cytometry. I. Methodology, theory and results for two distinct activators.Absence of ligands bound to glycoprotein IIB-IIIA on the exposed surface of a thrombus may limit thrombus growth in flowing blood.Transmembrane signaling across the platelet integrin glycoprotein IIb-IIIa.Regulated membrane-cytoskeleton linkages in platelets.The regulation of megakaryocyte polyploidization and its implications for coronary artery occlusion.Flow cytometric analysis of platelet activation and fibrinogen binding.Mouse T lymphoma cells contain a transmembrane glycoprotein (GP85) that binds ankyrin.Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cellsThe integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flankiIntegrins in point contacts mediate cell spreading: factors that regulate integrin accumulation in point contacts vs. focal contacts.Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit.Platelet membrane skeleton revealed by quick-freeze deep-etch.Dynamic redistribution of major platelet surface receptors after contact-induced platelet activation and spreading. An immunoelectron microscopy study.Proteolytic degradation of the RGD-binding and non-RGD-binding conformers of human platelet integrin glycoprotein IIb/IIIa: clues for identification of regions involved in the receptor's activationActivation-dependent changes in human platelet PECAM-1: phosphorylation, cytoskeletal association, and surface membrane redistribution.Detection of integrin alpha IIbbeta 3 clustering in living cells.Receptor-ligand complexes are cleared to the open canalicular system of surface-activated platelets.Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion.Platelet Alpha-granular Fibrinogen.
P2860
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P2860
The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
The platelet fibrinogen recept ...... nding and receptor clustering.
@en
type
label
The platelet fibrinogen recept ...... nding and receptor clustering.
@en
prefLabel
The platelet fibrinogen recept ...... nding and receptor clustering.
@en
P2093
P2860
P356
P1476
The platelet fibrinogen recept ...... nding and receptor clustering.
@en
P2093
D F Bainton
D R Phillips
M A Shuman
R P McEver
W M Isenberg
P2860
P304
P356
10.1083/JCB.104.6.1655
P407
P577
1987-06-01T00:00:00Z