Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.
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Regulation of glucose homeostasis by GLP-1Incretin-based drugs for type 2 diabetes: Focus on East Asian perspectivesLiraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic miceAnalysis of factors influencing postprandial C-peptide levels in Japanese patients with type 2 diabetes: Comparison with C-peptide levels after glucagon load.Targeting β-cell functions in therapy for type 2 diabetes.Efficacy and safety of sitagliptin monotherapy and combination therapy in Japanese type 2 diabetes patientsEfficacy and safety of alogliptin added to sulfonylurea in Japanese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial with an open-label, long-term extension studyEpac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytesExendin-4 pretreated adipose derived stem cells are resistant to oxidative stress and improve cardiac performance via enhanced adhesion in the infarcted heart.The stem cell adjuvant with Exendin-4 repairs the heart after myocardial infarction via STAT3 activation.Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe?Isoform-specific antagonists of exchange proteins directly activated by cAMPStimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium.Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A.Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets.β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East AsiansExenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages.Suppression of ROS Production by Exendin-4 in PSC Attenuates the High Glucose-Induced Islet Fibrosis.Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells.Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies.Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.Evogliptin: a new dipeptidyl peptidase inhibitor for the treatment of type 2 diabetes.Evidence for paracrine/autocrine regulation of GLP-1-producing cells.Identification of new key genes for type 1 diabetes through construction and analysis of protein-protein interaction networks based on blood and pancreatic islet transcriptomes.Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signalingReduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction.Further possible mechanisms of dipeptidyl peptidase-4 inhibitors to decrease blood glucose in subjects with type 2 diabetes.Epac-Rap signaling reduces oxidative stress in the tubular epithelium.Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling.Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats.Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function.
P2860
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P2860
Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Exendin-4 suppresses SRC activ ...... s in an Epac-dependent manner.
@en
type
label
Exendin-4 suppresses SRC activ ...... s in an Epac-dependent manner.
@en
prefLabel
Exendin-4 suppresses SRC activ ...... s in an Epac-dependent manner.
@en
P2093
P2860
P356
P1433
P1476
Exendin-4 suppresses SRC activ ...... s in an Epac-dependent manner.
@en
P2093
Chitose Oneyama
Hiroki Sato
Masato Okada
Mayumi Sasaki
Rieko Kominato
Shimpei Fujimoto
Yuichi Nishi
Yuichi Sato
P2860
P304
P356
10.2337/DB10-0021
P407
P577
2010-10-26T00:00:00Z