Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner. - Wikidata - wikimedia - TriplyDB

Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.

Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.

http://www.wikidata.org/entity/Q41531028

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Regulation of glucose homeostasis by GLP-1 Incretin-based drugs for type 2 diabetes: Focus on East Asian perspectives Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice Analysis of factors influencing postprandial C-peptide levels in Japanese patients with type 2 diabetes: Comparison with C-peptide levels after glucagon load.Targeting β-cell functions in therapy for type 2 diabetes.Efficacy and safety of sitagliptin monotherapy and combination therapy in Japanese type 2 diabetes patients Efficacy and safety of alogliptin added to sulfonylurea in Japanese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study Epac is required for GLP-1R-mediated inhibition of oxidative stress and apoptosis in cardiomyocytes Exendin-4 pretreated adipose derived stem cells are resistant to oxidative stress and improve cardiac performance via enhanced adhesion in the infarcted heart.The stem cell adjuvant with Exendin-4 repairs the heart after myocardial infarction via STAT3 activation.Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress.Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe?Isoform-specific antagonists of exchange proteins directly activated by cAMP Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium.Antidiabetic sulfonylureas and cAMP cooperatively activate Epac2A.Function and expression of sulfonylurea, adrenergic, and glucagon-like peptide 1 receptors in isolated porcine islets.β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians Exenatide (a GLP-1 agonist) improves the antioxidative potential of in vitro cultured human monocytes/macrophages.Suppression of ROS Production by Exendin-4 in PSC Attenuates the High Glucose-Induced Islet Fibrosis.Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β-cells.Does Glucagon-like Peptide-1 Ameliorate Oxidative Stress in Diabetes? Evidence Based on Experimental and Clinical Studies.Apolipoprotein CIII hyperactivates β cell CaV1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src.Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.Evogliptin: a new dipeptidyl peptidase inhibitor for the treatment of type 2 diabetes.Evidence for paracrine/autocrine regulation of GLP-1-producing cells.Identification of new key genes for type 1 diabetes through construction and analysis of protein-protein interaction networks based on blood and pancreatic islet transcriptomes.Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic GK rats by suppressing lactate overproduction.Further possible mechanisms of dipeptidyl peptidase-4 inhibitors to decrease blood glucose in subjects with type 2 diabetes.Epac-Rap signaling reduces oxidative stress in the tubular epithelium.Effects of Glucagon-Like Peptide-1 on Oxidative Stress and Nrf2 Signaling.Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats.Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function.

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Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.

http://www.wikidata.org/entity/Q41531028

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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2010年论文

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2010年论文

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name

Exendin-4 suppresses SRC activ ...... s in an Epac-dependent manner.

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Chitose Oneyama

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Eri Mukai

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Hiroki Sato

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Masato Okada

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Mayumi Sasaki

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Rieko Kominato

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Shimpei Fujimoto

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Yuichi Nishi

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Yuichi Sato

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P2860

Three-dimensional structure of the tyrosine kinase c-Src

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

The hunting of the Src

Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function

The Physiology of Glucagon-like Peptide 1

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

Biology of incretins: GLP-1 and GIP

Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae.

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