New protein engineering approaches to multivalent and bispecific antibody fragments.
about
Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy.High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domainCharacterization of Receptor Binding Profiles of Influenza A Viruses Using An Ellipsometry-Based Label-Free Glycan Microarray Assay Platform.Prevention of human rhinovirus infection by multivalent fab molecules directed against ICAM-1.Conformational stability as a design target to control protein aggregation.Designed auto-assembly of nanostreptabodies for rapid tissue-specific targeting in vivo.Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.Modulation of the CD40-CD40 ligand interaction using human anti-CD40 single-chain antibody fragments obtained from the n-CoDeR phage display library.ScFv multimers of the anti-neuraminidase antibody NC10: shortening of the linker in single-chain Fv fragment assembled in V(L) to V(H) orientation drives the formation of dimers, trimers, tetramers and higher molecular mass multimers.Selection of recombinant, library-derived antibody fragments against p24 for human immunodeficiency virus type 1 diagnostics.A recombinant bispecific single-chain Fv antibody against HLA class II and FcgammaRIII (CD16) triggers effective lysis of lymphoma cells.Cellular quality control screening to identify amino acid pairs for substituting the disulfide bonds in immunoglobulin fold domains.Screening phage display libraries for organ-specific vascular immunotargeting in vivoIsolation and comparative characterization of Ki-67 equivalent antibodies from the HuCAL phage display library.Selection of vimentin-specific antibodies from the HuCAL phage display library by subtractive panning on formalin-fixed, paraffin-embedded tissue.Multiple-antigen immunization of chickens facilitates the generation of recombinant antibodies to autoantigens.In vivo tumor targeting and imaging with engineered trivalent antibody fragments containing collagen-derived sequencesEngineering of stable bispecific antibodies targeting IL-17A and IL-23.A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo.Single-chain antibodies in pancreatic cancer.Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targetingEvolutionary self-organization of cell-free genetic coding.EGFR-targeted hybrid plasmonic magnetic nanoparticles synergistically induce autophagy and apoptosis in non-small cell lung cancer cells.Development of homomultimers and heteromultimers of lung cancer-specific peptoids.Kinetic analysis of novel mono- and multivalent VHH-fragments and their application for molecular imaging of brain tumours.Antibody constructs for radioimmunodiagnosis and treatment of human pancreatic cancer.A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model.Heptameric targeting ligands against EGFR and HER2 with high stability and avidity.Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds.Assessing combinatorial strategies to multimerize libraries of single-domain antibodies.Specificity of furanoside-protein recognition through antibody engineering and molecular modeling.Strategies to stabilize compact folding and minimize aggregation of antibody-based fragmentsLinking Single Domain Antibodies that Recognize Different Epitopes on the Same Target.scFv antibody: principles and clinical applicationHitting multiple targets with multimeric ligands.Engineering tandem single-chain Fv as cell surface reporters with enhanced properties of fluorescence detection.Immunoscreening protocols for the identification of clinically useful antibodies and antigens.Tailoring antibodies for radionuclide delivery.Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma.Self-assembly of antibodies by chemical induction
P2860
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P2860
New protein engineering approaches to multivalent and bispecific antibody fragments.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
New protein engineering approaches to multivalent and bispecific antibody fragments.
@en
type
label
New protein engineering approaches to multivalent and bispecific antibody fragments.
@en
prefLabel
New protein engineering approaches to multivalent and bispecific antibody fragments.
@en
P1476
New protein engineering approaches to multivalent and bispecific antibody fragments.
@en
P2093
P304
P356
10.1016/S1380-2933(97)00067-5
P577
1997-06-01T00:00:00Z