New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro.

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Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo.Ginger (Zingiber officinale) phytochemicals-gingerenone-A and shogaol inhibit SaHPPK: molecular docking, molecular dynamics simulations and in vitro approaches.

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New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro.

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2017 nî lūn-bûn

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2017年の論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年論文

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2017年论文

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2017年论文

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2017年论文

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name

New compounds identified throu ...... rolyl oligopeptidase in vitro.

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type

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New compounds identified throu ...... rolyl oligopeptidase in vitro.

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New compounds identified throu ...... rolyl oligopeptidase in vitro.

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P1476

New compounds identified throu ...... prolyl oligopeptidase in vitro

@en

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Ayoung Baek

http://www.w3.org/2001/XMLSchema#string

Keun Woo Lee

http://www.w3.org/2001/XMLSchema#string

Min Gi Jo

http://www.w3.org/2001/XMLSchema#string

Myeong Ok Kim

http://www.w3.org/2001/XMLSchema#string

Raj Kumar

http://www.w3.org/2001/XMLSchema#string

Shailima Rampogu

http://www.w3.org/2001/XMLSchema#string

Venkatesh Arulalapperumal

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SwissParam: A fast force field generation tool for small organic molecules

Electrostatic effects and binding determinants in the catalysis of prolyl oligopeptidase. Site specific mutagenesis at the oxyanion binding site

Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)

Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide

Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

S 17092: a prolyl endopeptidase inhibitor as a potential therapeutic drug for memory impairment. Preclinical and clinical studies

Exploration of Novel Inhibitors for Bruton's Tyrosine Kinase by 3D QSAR Modeling and Molecular Dynamics Simulation

ChemSpider: An Online Chemical Information Resource

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit.

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s41598-017-11302-0

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scholarly article

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10.1038/S41598-017-11302-0

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English

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Rohit S. Bavi

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2017-09-07T00:00:00Z

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28883518

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Synuclein

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5589771

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New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro.

about

P2860

P2860

New compounds identified through in silico approaches reduce the α-synuclein expression by inhibiting prolyl oligopeptidase in vitro.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932

P356

P1433

P1476

P2093

P2860

P2888

P304

P31

P356

P407

P433

P478

P50

P577

P698

P921

P932