about
Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporterComparative Study of the Synthesis and Structural and Physicochemical Properties of Diketopiperazines vs Aza-diketopiperazines.Use of a fluorescent polarization based high throughput assay to identify new calmodulin ligands.Solid-phase preparation of a pilot library derived from the 2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-amine scaffold.Solid-phase organic tagging resins for labeling biomolecules by 1,3-dipolar cycloaddition: application to the synthesis of a fluorescent non-peptidic vasopressin receptor ligand.Small neutralizing molecules to inhibit actions of the chemokine CXCL12.Identification and pharmacological properties of E339-3D6, the first nonpeptidic apelin receptor agonist.Combinatorial aid for underprivileged scaffolds: solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (Aza-DKP).Neutralizing endogenous chemokines with small molecules. Principles and potential therapeutic applications.Involvement of the TGFβ pathway in the regulation of α5 β1 integrins by caveolin-1 in human glioblastoma.Prodrugs of a CXC Chemokine-12 (CXCL12) Neutraligand Prevent Inflammatory Reactions in an Asthma Model in Vivo.alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells.Increasing cellular immunogenicity to peptide-based vaccine candidates using a fluorocarbon antigen delivery system.Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus.Synthesis by chemoselective ligation and biological evaluation of novel cell-permeable PKC-zeta pseudosubstrate lipopeptides.Chemoselective acylation of fully deprotected hydrazino acetyl peptides. Application to the synthesis of lipopetides.Simultaneous lipidation of a characterized peptide mixture by chemoselective ligation.Solid-phase functionalization of peptides by an alpha-hydrazinoacetyl group.A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis.New fluorescein precursors for live bacteria detection.Structure-activity relationship studies toward the discovery of selective apelin receptor agonists.From the Promiscuous Asenapine to Potent Fluorescent Ligands Acting at a Series of Aminergic G-Protein-Coupled Receptors.A Time-Resolved FRET Cell-Based Binding Assay for the Apelin Receptor.Convenient Access to Fluorescent Probes by Chemoselective Acylation of Hydrazinopeptides: Application to the Synthesis of the First Far-Red Ligand for Apelin Receptor Imaging.Squaraine as a bright, stable and environment-sensitive far-red label for receptor-specific cellular imaging.Fluorogenic squaraine dimers with polarity-sensitive folding as bright far-red probes for background-free bioimaging.Red fluorescent turn-on ligands for imaging and quantifying G protein-coupled receptors in living cells.Fluorescent derivatives of AC-42 to probe bitopic orthosteric/allosteric binding mechanisms on muscarinic M1 receptors.Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer.Diastereoselective synthesis of novel aza-diketopiperazines via a domino cyclohydrocarbonylation/addition process.Solid-Phase Synthesis of Tetrahydro-β-carbolinehydantoins via theN-Acyliminium Pictet−Spengler Reaction and Cyclative CleavageReactivity of Lys(NH2)-containing peptides toward endopeptidases.Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in miceSynthesis of hydrazinopeptides using solid-phase N-electrophilic amination: extension to the Fmoc/tert-butyl strategy and chemistry of the N-N bond in strong acid mediaConvenient method to access new 4,4-dialkoxy- and 4,4-diaryloxy-diaza-s-indacene dyes: Synthesis and spectroscopic evaluationSelective nonpeptidic fluorescent ligands for oxytocin receptor: design, synthesis, and application to time-resolved FRET binding assayPharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgeryDiscovery of a Locally and Orally Active CXCL12 Neutraligand (LIT-927) with Anti-inflammatory Effect in a Murine Model of Allergic Airway HypereosinophiliaVersatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines
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description
researcher
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wetenschapper
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հետազոտող
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name
Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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type
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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prefLabel
Dominique Bonnet
@ast
Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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Dominique Bonnet
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P1053
N-7275-2014
P106
P2798
P31
P3829
P496
0000-0002-8252-9199