A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning - Wikidata - wikimedia - TriplyDB

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

http://www.wikidata.org/entity/Q24657785

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Leveraging the cortical cholinergic system to enhance attention Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM Alzheimer's disease: Targeting the Cholinergic System M1 and M3 muscarinic receptors may play a role in the neurotoxicity of anhydroecgonine methyl ester, a cocaine pyrolysis product The antipsychotic potential of muscarinic allosteric modulation Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders.Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents.Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100 Knockdown of phospholipase C-β1 in the medial prefrontal cortex of male mice impairs working memory among multiple schizophrenia endophenotypes Targeting selective activation of M(1) for the treatment of Alzheimer's disease: further chemical optimization and pharmacological characterization of the M(1) positive allosteric modulator ML169.Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia Targeting glutamate synapses in schizophrenia Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia.Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model.Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.Allosteric Modulation of Muscarinic Acetylcholine Receptors.The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking.Modes and models of forebrain cholinergic neuromodulation of cognition.Development of allosteric modulators of GPCRs for treatment of CNS disorders Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Crystal structures of the M1 and M4 muscarinic acetylcholine receptors Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.The hippocampo-prefrontal pathway: a possible therapeutic target for negative and cognitive symptoms of schizophrenia Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators.A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice.A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models Muscarinic receptors modulate the intrinsic excitability of infralimbic neurons and consolidation of fear extinction.Role for the M1 Muscarinic Acetylcholine Receptor in Top-Down Cognitive Processing Using a Touchscreen Visual Discrimination Task in Mice Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations.An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory.Development of M1 mAChR allosteric and bitopic ligands: prospective therapeutics for the treatment of cognitive deficits M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.Muscarinic receptors: their roles in disorders of the central nervous system and potential as therapeutic targets.Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease.

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P2860

A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

http://www.wikidata.org/entity/Q24657785

description

2009 nî lūn-bûn

@nan

2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

A selective allosteric potenti ...... pairments in reversal learning

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A selective allosteric potenti ...... pairments in reversal learning

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type

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A selective allosteric potenti ...... pairments in reversal learning

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A selective allosteric potenti ...... pairments in reversal learning

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A selective allosteric potenti ...... pairments in reversal learning

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JNEUROSCI.3930-09.2009

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Journal of Neuroscience

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A selective allosteric potenti ...... pairments in reversal learning

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Albert A Davis

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Allan I Levey

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Ashley E Brady

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Dean H Snyder

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Edward P Christian

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J Phillip Kennedy

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James J Doherty

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James J Lah

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Jana K Shirey

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Michael C Quirk

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P2860

Cholinesterase inhibitors for Alzheimer's disease

An integrative theory of prefrontal cortex function

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia.

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity.

Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins

The cholinergic hypothesis of geriatric memory dysfunction

Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia

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14271-86

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scholarly article

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10.1523/JNEUROSCI.3930-09.2009

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45

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29

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Craig W. Lindsley

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2009-11-11T00:00:00Z

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19906975

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2811323

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