about
Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cellsDistinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virusSelective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subsetSkin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infectionDistinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1Protective immunity to liver-stage malariaThe clonal selection theory: 50 years since the revolutionProteomic and metabolomic analyses of mitochondrial complex I-deficient mouse model generated by spontaneous B2 short interspersed nuclear element (SINE) insertion into NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) genePersistence of skin-resident memory T cells within an epidermal niche.Multiple dendritic cell populations activate CD4+ T cells after viral stimulation.Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.Up-regulation of LFA-1 allows liver-resident memory T cells to patrol and remain in the hepatic sinusoids.Cross-presentation in viral immunity and self-tolerance.Latent infection with herpes simplex virus is associated with ongoing CD8+ T-cell stimulation by parenchymal cells within sensory gangliaEpidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells.Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation.Cognate CD4(+) T cell licensing of dendritic cells in CD8(+) T cell immunity.The early expression of glycoprotein B from herpes simplex virus can be detected by antigen-specific CD8+ T cells.The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.The role of dendritic cell subsets in selection between tolerance and immunity.CD8+ T cells from a novel T cell receptor transgenic mouse induce liver-stage immunity that can be boosted by blood-stage infection in rodent malaria.Helper T cells, dendritic cells and CTL Immunity.Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens.Targeting Dendritic Cells in vivo for Cancer Therapy.Long-lived epithelial immunity by tissue-resident memory T (TRM) cells in the absence of persisting local antigen presentation.Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity.Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection.Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: limitations of the Langerhans cells paradigm.Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cellsGamma interferon-independent effects of interleukin-12 on immunity to Salmonella enterica serovar Typhimurium.DEC-205 is a cell surface receptor for CpG oligonucleotides.Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by BimSOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation.SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential.Blood-stage Plasmodium infection induces CD8+ T lymphocytes to parasite-expressed antigens, largely regulated by CD8alpha+ dendritic cells.The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancementToo dangerous to ignore: self-tolerance and the control of ignorant autoreactive T cells.
P50
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P50
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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William Heath
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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William R Heath
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P106
P1960
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P21
P31
P496
0000-0001-9670-259X