Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
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Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosisLymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim.BH3-only proteins in rheumatoid arthritis: potential targets for therapeutic intervention.Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation.The power and the promise of restimulation-induced cell death in human immune diseases.Inflammation programs self-reactive CD8+ T cells to acquire T-box-mediated effector function but does not prevent deletional toleranceThe many roles of FAS receptor signaling in the immune systemBcl-2-regulated cell death signalling in the prevention of autoimmunity.T helper lymphocytes rescue CTL from activation-induced cell death.The essential role of evasion from cell death in cancer.Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells.Caspase-8 inactivation in T cells increases necroptosis and suppresses autoimmunity in Bim-/- mice.Antibody-enhanced cross-presentation of self antigen breaks T cell tolerance.T cell apoptosis and inflammatory bowel disease.T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens.Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T CellsBax does not have to adopt its final form to drive T cell deathAntigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells.Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient miceFunctional reprogramming of the primary immune response by T cell receptor antagonism.SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential.The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunityBim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer.Durable adoptive immunotherapy for leukemia produced by manipulation of multiple regulatory pathways of CD8+ T-cell tolerance.Autoimmunity versus tolerance: can dying cells tip the balance?Critical role for BIM in T cell receptor restimulation-induced deathApoptotic signal transduction and T cell tolerance.T-cell death and cancer immune tolerance.What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain.The cell biology of cross-presentation and the role of dendritic cell subsets.The molecular signature of CD8+ T cells undergoing deletional toleranceIn vitro and in vivo differentiated effector CD8 T cells display divergent histone acetylation patterns within the Ifng locusDiversity in CD8(+) T cell differentiation.Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells.The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance.Shaping the T-cell repertoire in the periphery.Immunological perspective of self versus tumor antigens: insights from the RIP-gp model.
P2860
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P2860
Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Peripheral deletion of autorea ...... itable pathway mediated by Bim
@ast
Peripheral deletion of autorea ...... itable pathway mediated by Bim
@en
type
label
Peripheral deletion of autorea ...... itable pathway mediated by Bim
@ast
Peripheral deletion of autorea ...... itable pathway mediated by Bim
@en
prefLabel
Peripheral deletion of autorea ...... itable pathway mediated by Bim
@ast
Peripheral deletion of autorea ...... itable pathway mediated by Bim
@en
P2093
P2860
P50
P356
P1476
Peripheral deletion of autorea ...... itable pathway mediated by Bim
@en
P2093
Christian Kurts
Francis R Carbone
Jacques F A P Miller
P2860
P304
P356
10.1084/JEM.20020827
P407
P577
2002-10-01T00:00:00Z