Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.
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Quantitative challenges in understanding ligand discrimination by alphabeta T cellsModeling T cell antigen discrimination based on feedback control of digital ERK responsesIdentifying Individual T Cell Receptors of Optimal Avidity for Tumor AntigensTCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeysT cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surfaceStructural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptorHow a T Cell Receptor-like Antibody Recognizes Major Histocompatibility Complex-bound Peptideαβ T cell receptors as predictors of health and diseaseQuantifying signaling-induced reorientation of T cell receptors during immunological synapse formation.T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APCEvidence for a functional sidedness to the alphabetaTCR.Analyzing surface plasmon resonance data: choosing a correct biphasic model for interpretation.The SCHOOL of nature: I. Transmembrane signaling.The Goldilocks model for TCR-too much attraction might not be best for vaccine designThe impact of TCR-binding properties and antigen presentation format on T cell responsiveness.Molecular interactions between extracellular components of the T-cell receptor signaling complex.Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection.Fast on-rates allow short dwell time ligands to activate T cells.Paradoxical intrathymic positive selection in mice with only a covalently presented agonist peptideSequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses.The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.Contribution of TCR signaling strength to CD8+ T cell peripheral tolerance mechanismsHow the immune system works to protect the host from infection: a personal view.Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramersComputational analysis of T cell receptor signaling and ligand discrimination--past, present, and future.The SCHOOL of nature: III. From mechanistic understanding to novel therapiesInterleukin-15:Interleukin-15 receptor α scaffold for creation of multivalent targeted immune moleculesA conformational change senses the strength of T cell receptor-ligand interaction during thymic selection.Signaling in thymic selection.A role for CD8 in the developmental tuning of antigen recognition and CD3 conformational change.On the issue of peptide recognition in T cell development.Opposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulationCooperative enhancement of specificity in a lattice of T cell receptors.Insights into T cell recognition of antigen: significance of two-dimensional kinetic parametersGads regulates the expansion phase of CD8+ T cell-mediated immunity.Kinetic evidence for a ligand-binding-induced conformational transition in the T cell receptorSystemic immunomodulation of autoimmune disease using MHC-derived recombinant TCR ligands
P2860
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P2860
Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Qualitative and quantitative d ...... gonist and antagonist ligands.
@en
type
label
Qualitative and quantitative d ...... gonist and antagonist ligands.
@en
prefLabel
Qualitative and quantitative d ...... gonist and antagonist ligands.
@en
P2093
P1433
P1476
Qualitative and quantitative d ...... agonist and antagonist ligands
@en
P2093
G M Davies
K A Hogquist
N R Gascoigne
P J Travers
S C Jameson
W Nasholds
P304
P356
10.1016/S1074-7613(00)80023-0
P407
P50
P577
1999-02-01T00:00:00Z