Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.
about
Fibroblasts, an inconspicuous but essential player in colon cancer development and progressionThe gastrointestinal tumor microenvironmentTumor progression locus 2 (Tpl2) kinase as a novel therapeutic target for cancer: double-sided effects of Tpl2 on cancerPrimary Myofibroblasts Maintain Short-Term Viability following Submucosal Injection in Syngeneic, Immune-Competent Mice Utilizing Murine ColonoscopyIKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.Tpl2 knockout keratinocytes have increased biomarkers for invasion and metastasisFour individually druggable MET hotspots mediate HGF-driven tumor progression.TPL2 kinase regulates the inflammatory milieu of the myeloma nicheIntestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis.Tumor progression locus 2 differentially regulates IFNγ and IL-17 production by effector CD4+ T cells in a T cell transfer model of colitisInflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges.TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.IKKβ in intestinal mesenchymal cells promotes initiation of colitis-associated cancer.Mechanistic roles of epithelial and immune cell signaling during the development of colitis-associated cancer.Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.Epimorphin deletion inhibits polyposis in the Apcmin/+ mouse model of colon carcinogenesis via decreased myofibroblast HGF secretion.miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma.Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancer-associated fibroblast accumulation.The emerging role of hepatocyte growth factor in renal diseases.Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment.Physical and functional interaction of the TPL2 kinase with nucleophosmin.Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in miceCD90(+) Stromal Cells are Non-Professional Innate Immune Effectors of the Human Colonic Mucosa.Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice.TPL2 is a key regulator of intestinal inflammation in C. difficile infection.
P2860
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P2860
Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Tpl2 regulates intestinal myof ...... itis-associated tumorigenesis.
@en
type
label
Tpl2 regulates intestinal myof ...... itis-associated tumorigenesis.
@en
prefLabel
Tpl2 regulates intestinal myof ...... itis-associated tumorigenesis.
@en
P2860
P50
P356
P1476
Tpl2 regulates intestinal myof ...... litis-associated tumorigenesis
@en
P2093
Manolis Roulis
Vasiliki Koliaraki
P2860
P304
P356
10.1172/JCI63917
P407
P577
2012-10-15T00:00:00Z