about
Conformational sampling and nucleotide-dependent transitions of the GroEL subunit probed by unbiased molecular dynamics simulationsStructural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stabilityThe N-Terminal Sequence of Tyrosine Hydroxylase Is a Conformationally Versatile Motif That Binds 14-3-3 Proteins and MembranesStructural and thermodynamic insight into phenylalanine hydroxylase from the human pathogenLegionella pneumophilaCrystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuriaDynamics, flexibility, and allostery in molecular chaperoninsThree-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranesSelectivity and affinity determinants for ligand binding to the aromatic amino acid hydroxylasesTyrosine Hydroxylase Binding to Phospholipid Membranes Prompts Its Amyloid Aggregation and Compromises Bilayer Integrity.HAMLET interacts with lipid membranes and perturbs their structure and integrity.Rescue of misfolded proteins and stabilization by small molecules.Allosteric communication between cAMP binding sites in the RI subunit of protein kinase A revealed by NMRThe regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation.Identification of a novel lytic peptide for the treatment of solid tumours.Phosphorylation dependence and stoichiometry of the complex formed by tyrosine hydroxylase and 14-3-3γ.Formation of the iron-oxo hydroxylating species in the catalytic cycle of aromatic amino acid hydroxylases.Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure.Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry.Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.Conformational flexibility of alpha-lactalbumin related to its membrane binding capacity.The peripheral binding of 14-3-3γ to membranes involves isoform-specific histidine residues.Phenylalanine hydroxylase misfolding and pharmacological chaperones.Linking genotypes database with locus-specific database and genotype-phenotype correlation in phenylketonuriaCuticle integrity and biogenic amine synthesis in Caenorhabditis elegans require the cofactor tetrahydrobiopterin (BH4).Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism.Pharmacological Chaperoning: A Potential Treatment for PMM2-CDG.Large-scale modulation of thermodynamic protein folding barriers linked to electrostaticsIdentification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria.Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.The 14-3-3 proteins in regulation of cellular metabolism.Phenylalanine hydroxylase: function, structure, and regulation.Partial characterization and three-dimensional-structural localization of eight mutations in exon 7 of the human phenylalanine hydroxylase gene associated with phenylketonuria.Pharmacological Chaperones that Protect Tetrahydrobiopterin Dependent Aromatic Amino Acid Hydroxylases Through Different Mechanisms.Arc is a flexible modular protein capable of reversible self-oligomerization.Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme.Divergence in enzyme regulation between Caenorhabditis elegans and human tyrosine hydroxylase, the key enzyme in the synthesis of dopamine.Overview of computational methods employed in early-stage drug discovery.Effect of nerve injury on the number of dorsal root ganglion neurons and autotomy behavior in adult Bax-deficient mice.Structural and stability effects of phosphorylation: Localized structural changes in phenylalanine hydroxylase
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Aurora Martinez
@ast
Aurora Martinez
@en
Aurora Martinez
@es
Aurora Martinez
@nl
type
label
Aurora Martinez
@ast
Aurora Martinez
@en
Aurora Martinez
@es
Aurora Martinez
@nl
altLabel
Martinez A
@en
prefLabel
Aurora Martinez
@ast
Aurora Martinez
@en
Aurora Martinez
@es
Aurora Martinez
@nl
P1053
G-4265-2012
P106
P21
P31
P4012
P496
0000-0003-1643-6506