Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain.
about
Molecular cloning reveals that the p160 Myb-binding protein is a novel, predominantly nucleolar protein which may play a role in transactivation by MybWnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLKTRAF7 sequesters c-Myb to the cytoplasm by stimulating its sumoylation.Only the DNA binding and transactivation domains of c-Myb are required to block terminal differentiation of murine erythroleukemia cellsMechanism of c-myc regulation by c-Myb in different cell lineages.Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain.Identification of protein instability determinants in the carboxy-terminal region of c-Myb removed as a result of retroviral integration in murine monocytic leukemias.Transformation of chicken myelomonocytic cells by a retrovirus expressing the v-myb oncogene from the long terminal repeats of avian myeloblastosis virus but not Rous sarcoma virus.Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL.Myb controls G(2)/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc.MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.Ectopic expression of A-myb in transgenic mice causes follicular hyperplasia and enhanced B lymphocyte proliferation.Opposing actions of c-ets/PU.1 and c-myb protooncogene products in regulating the macrophage-specific promoters of the human and mouse colony-stimulating factor-1 receptor (c-fms) genes.Myb proteins: angels and demons in normal and transformed cells.Transactivation and transformation by Myb are negatively regulated by a leucine-zipper structure.Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis.Overexpression of C-terminally but not N-terminally truncated Myb induces fibrosarcomas: a novel nonhematopoietic target cell for the myb oncogene.Influence of the v-Myb transactivation domain on the oncoprotein's transformation specificityA common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergyTranscriptional activation of a retrovirus enhancer by CBF (AML1) requires a second factor: evidence for cooperativity with c-Myb.The carboxyterminus of human c-myb protein stimulates activated transcription in trans.Positive and negative regulation of c-Myb by cyclin D1, cyclin-dependent kinases, and p27 Kip1.Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae.A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding.The glucocorticoid receptor is a key regulator of the decision between self-renewal and differentiation in erythroid progenitors.A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity
P2860
Q24523971-7F4A606E-1D2A-4134-93B1-40E14A465967Q24624946-6C65E0BA-B68A-43A0-9DE5-AB7E9E8338E0Q28509337-5947CEE2-DFF3-477C-A15A-A7FDCCF28F12Q30450271-B222F7F7-A269-4FB3-967E-6433DD8F02CDQ30450274-A67EBCC0-3A66-426F-B163-0761B4CF8190Q30453947-38A4202D-A4D1-4FD5-ADFC-905E97F372FBQ33653102-2AFE60BD-4F9E-405B-98C8-59891F3F1B6EQ33935542-82392E22-465D-41B2-BB5B-26F95DF72C23Q33996833-057EEA19-64C5-4EB2-8099-1A73B89577A8Q34078260-689FA2E1-431B-4A65-A2B6-469CACC4E113Q34511655-23792892-ED72-4087-85B3-2C455A443585Q36083792-E8A9A683-4CF3-40C0-B309-F9B1E1CC644EQ36364154-02348A67-7EC4-4E19-85FD-CBE45614B981Q36603616-390BAD14-062F-4D24-A3CF-5CB31B64CF9AQ36937297-66922625-2BBD-44F4-9929-98A5B7D87FDFQ38256411-F2B9D02F-EA7F-4A5A-B764-906932CC37F0Q38309586-43EDD006-D731-4D01-9AC2-29086943885BQ38320342-69EC2432-459C-4397-9DB3-44EC7C70F2DDQ39454884-1E6895A5-C178-4C83-BF3D-80F69B5C1DECQ39875687-089E0D73-EDD6-443D-BD5F-DCB3BE9F60E0Q40400370-8056935E-F33B-4157-B1DC-EA468D7EF647Q40462726-9FAC0FC2-7E8B-4352-A682-390F962BFCC7Q41545032-5B1AC510-CB5E-4AED-BAE6-98507FB0EC9BQ41936960-375A94EE-A6E2-4E08-9FDE-FF16898889E1Q42609240-E5E34C7D-F67A-43D0-8505-CD172C597100Q58769223-B312D4A2-1E49-4546-8F30-5153FEB79B37
P2860
Transformation by carboxyl-deleted Myb reflects increased transactivating capacity and disruption of a negative regulatory domain.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Transformation by carboxyl-del ...... a negative regulatory domain.
@en
type
label
Transformation by carboxyl-del ...... a negative regulatory domain.
@en
prefLabel
Transformation by carboxyl-del ...... a negative regulatory domain.
@en
P2093
P1433
P1476
Transformation by carboxyl-del ...... a negative regulatory domain.
@en
P2093
P304
P407
P577
1991-09-01T00:00:00Z