Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.
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A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteriaNatural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylationCrystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesisCrystal structure of StaL, a glycopeptide antibiotic sulfotransferase from Streptomyces toyocaensisCrystal Structures of the Glycopeptide Sulfotransferase Teg12 in a Complex with the Teicoplanin AglyconeStructural Characterization of OxyD, a Cytochrome P450 Involved in -Hydroxytyrosine Formation in Vancomycin BiosynthesisThe 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesisMore than just recruitment: the X-domain influences catalysis of the first phenolic coupling reaction in A47934 biosynthesis by Cytochrome P450 StaHKinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation CycleSolid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria.Thermodynamic and kinetic properties of trans-3,4,5,6-tetramethyl-9, 10-dihydroxy-9,10-dihydrophenanthrene: pseudo-rotational barriers around biphenyl axis.Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibraryTailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural productsAn aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors.Highly efficient carbazolyl-derived phosphine ligands: application to sterically hindered biaryl couplings.Emerging themes in medicinal glycoscience.Enantioselective synthesis of axially chiral biaryls by the Pd-catalyzed Suzuki-Miyaura reaction: substrate scope and quantum mechanical investigationsLight scattered by model phantom bacteria reveals molecular interactions at their surface.The evolving role of chemical synthesis in antibacterial drug discovery.Molecular interactions of glycopeptide antibiotics investigated by affinity capillary electrophoresis and bioaffinity electrospray ionization-mass spectrometry.Vancomycin resistance: small molecule approaches targeting the bacterial cell wall biosynthesis.From nature to the laboratory and into the clinicMechanism of action of oritavancin and related glycopeptide antibiotics.Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers.Structure diversification of vancomycin through peptide-catalyzed, site-selective lipidation: a catalysis-based approach to combat glycopeptide-resistant pathogens.Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptideTotal synthesis of [Ψ[C(═S)NH]Tpg4]vancomycin aglycon, [Ψ[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.Atropisomerism, biphenyls, and fluorine: a comparison of rotational barriers and twist angles.The essence of total synthesisSite-selective bromination of vancomycin.Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffoldConstructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance.Arylglycine-derivative synthesis via oxidative sp(3) C-H functionalization of α-amino esters.A stepwise dechlorination/cross-coupling strategy to diversify the vancomycin 'in-chloride'.Studies toward the total synthesis of ristocetin A aglycone using arene-ruthenium complexes as S(N)Ar substrates: Construction of an advanced tricyclic intermediateTotal synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding.Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds.Recurrent Challenges for Clinicians: Emergence of Methicillin-Resistant Staphylococcus aureus, Vancomycin Resistance, and Current Treatment Options.Carrier protein substrates in cytochrome P450-catalysed oxidation.
P2860
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P2860
Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.
@en
type
label
Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.
@en
prefLabel
Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.
@en
P2093
P1433
P1476
Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics.
@en
P2093
P304
P356
10.1002/(SICI)1521-3773(19990802)38:15<2096::AID-ANIE2096>3.0.CO;2-F
P577
1999-08-01T00:00:00Z