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DDX3 regulates cell growth through translational control of cyclin E1The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradationA dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapyBinding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycleAlternative cyclin D1 splice forms differentially regulate the DNA damage responseMicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7Unbalanced replication as a major source of genetic instability in cancer cellsDiversity of degradation signals in the ubiquitin-proteasome systemReplication licensing and cancer--a fatal entanglement?The cyclin E/Cdk2 substrate p220(NPAT) is required for S-phase entry, histone gene expression, and Cajal body maintenance in human somatic cellsp27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapyEstrogen regulation of cyclin E2 requires cyclin D1 but not c-MycIsoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligaseAnalysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)The spindle checkpoint requires cyclin-dependent kinase activityCyclins in breast cancer: too much of a good thing.Chromosomal instability and lack of cyclin E regulation in hCdc4 mutant human breast cancer cellsLow-molecular-weight cyclin E: the missing link between biology and clinical outcomeTargeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels.Oncolytic Replication of E1b-Deleted AdenovirusesNetwork calisthenics: control of E2F dynamics in cell cycle entryDistinct mechanisms control the stability of the related S-phase cyclins Clb5 and Clb6.Centrosome - a promising anti-cancer targetHuman F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell linePathways governing G1/S transition and their response to DNA damageMMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancerThe structure of cyclin E1/CDK2: implications for CDK2 activation and CDK2-independent rolesDNA damage response genes and the development of cancer metastasisRole of cell cycle regulators in lung carcinogenesisCharacterization of cyclin E expression in multiple myeloma and its functional role in seliciclib-induced apoptotic cell deathMolecular basis for viral selective replication in cancer cells: activation of CDK2 by adenovirus-induced cyclin ETargeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplicationEstrogen mediates Aurora-A overexpression, centrosome amplification, chromosomal instability, and breast cancer in female ACI ratsThe NEDD8 system is essential for cell cycle progression and morphogenetic pathway in miceActivation of the DNA damage checkpoint and genomic instability in human precancerous lesionsAcute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation.Cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1).Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stressDeregulated ERK1/2 MAP kinase signaling promotes aneuploidy by a Fbxw7β-Aurora A pathway
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Deregulated cyclin E induces chromosome instability.
@en
type
label
Deregulated cyclin E induces chromosome instability.
@en
prefLabel
Deregulated cyclin E induces chromosome instability.
@en
P2093
P356
P1433
P1476
Deregulated cyclin E induces chromosome instability.
@en
P2093
P2888
P304
P356
10.1038/45836
P407
P577
1999-09-01T00:00:00Z
P6179
1005965021