about
Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2.The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor proteinAssociation of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1Carboxy terminus of human herpesvirus 8 latency-associated nuclear antigen mediates dimerization, transcriptional repression, and targeting to nuclear bodies.VP16 targets an amino-terminal domain of HCF involved in cell cycle progressionN-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motifA cultured affair: HSV latency and reactivation in neuronsTransient reversal of episome silencing precedes VP16-dependent transcription during reactivation of latent HSV-1 in neuronsRestarting Lytic Gene Transcription at the Onset of Herpes Simplex Virus ReactivationA cell culture model of facial palsy resulting from reactivation of latent herpes simplex type 1.Immune Escape via a Transient Gene Expression Program Enables Productive Replication of a Latent Pathogen.A primary neuron culture system for the study of herpes simplex virus latency and reactivation.Activation of host translational control pathways by a viral developmental switchModeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons.DNA replication facilitates the action of transcriptional enhancers in transient expression assays.Cooperation between viral interferon regulatory factor 4 and RTA to activate a subset of Kaposi's sarcoma-associated herpesvirus lytic promotersControl of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor.Setting the stage for S phase.Wide-scale use of Notch signaling factor CSL/RBP-Jkappa in RTA-mediated activation of Kaposi's sarcoma-associated herpesvirus lytic genesViral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors.Transcripts encoding K12, v-FLIP, v-cyclin, and the microRNA cluster of Kaposi's sarcoma-associated herpesvirus originate from a common promoter.Transcriptional activation by the Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen is facilitated by an N-terminal chromatin-binding motif.A single-point mutation in HCF causes temperature-sensitive cell-cycle arrest and disrupts VP16 function.Cultured vestibular ganglion neurons demonstrate latent HSV1 reactivation.Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons.The latency-associated nuclear antigen interacts with MeCP2 and nucleosomes through separate domainsExpression of herpes simplex virus 1 microRNAs in cell culture models of quiescent and latent infection.Shared ancestry of herpes simplex virus 1 strain Patton with recent clinical isolates from Asia and with strain KOS63.Using homogeneous primary neuron cultures to study fundamental aspects of HSV-1 latency and reactivation.Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces a strong bend on binding to terminal repeat DNA.Combinatorial control of transcription: the herpes simplex virus VP16-induced complex.The gene encoding the VP16-accessory protein HCF (HCFC1) resides in human Xq28 and is highly expressed in fetal tissues and the adult kidney.Going the distance: optimizing RNA-Seq strategies for transcriptomic analysis of complex viral genomesDirect RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogenTOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus LatencyEvaluation of extrachromosomal gene copy number of transiently transfected cell lines2019 Colorado Alphaherpesvirus Latency Society symposiumUsing Primary SCG Neuron Cultures to Study Molecular Determinants of HSV-1 Latency and ReactivationUsing Direct RNA Nanopore Sequencing to Deconvolute Viral Transcriptomes
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Angus C Wilson
@ast
Angus C Wilson
@en
Angus C Wilson
@es
type
label
Angus C Wilson
@ast
Angus C Wilson
@en
Angus C Wilson
@es
altLabel
Angus C Wilson
@en
prefLabel
Angus C Wilson
@ast
Angus C Wilson
@en
Angus C Wilson
@es
P106
P21
P31
P496
0000-0002-5016-4164