The alpha 1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1.
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HLA-DR alpha 2 mediates negative signalling via binding to Tirc7 leading to anti-inflammatory and apoptotic effects in lymphocytes in vitro and in vivoCytokine response by human monocytes to Clostridium difficile toxin A and toxin BSequences in both class II major histocompatibility complex alpha and beta chains contribute to the binding of the superantigen toxic shock syndrome toxin 1Understanding the mechanism of action of bacterial superantigens from a decade of research.Retroviral super-antigens and T cells.Dual antigenic recognition by cloned human gamma delta T cells.Dendritic cells are potent antigen-presenting cells for microbial superantigensClostridium perfringens enterotoxin is a superantigen reactive with human T cell receptors V beta 6.9 and V beta 22Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen.Tumorigenicity conferred to lymphoma mutant by major histocompatibility complex-encoded transporter gene.T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen.Identification of class II major histocompatibility complex and T cell receptor binding sites in the superantigen toxic shock syndrome toxin 1An insulin peptide that binds an alternative site in class II major histocompatibility complex.Regulation of Apoptosis by Gram-Positive Bacteria: Mechanistic Diversity and Consequences for Immunity.Distinct binding sites on HLA-DR for invariant chain and staphylococcal enterotoxins.Both alpha-helices along the major histocompatibility complex binding cleft are required for staphylococcal enterotoxin A function.Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents.Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR.Temporal sequence and kinetics of proinflammatory and anti-inflammatory cytokine secretion induced by toxic shock syndrome toxin 1 in human peripheral blood mononuclear cells.Biological activity of toxic shock syndrome toxin 1 and a site-directed mutant, H135A, in a lipopolysaccharide-potentiated mouse lethality model.Bacterial pyrogenic exotoxins as superantigens.Relative abilities of distinct isotypes of human major histocompatibility complex class II molecules to bind streptococcal pyrogenic exotoxin types A and B.Bacterial superantigens--mechanism of T cell activation by the superantigens and their role in the pathogenesis of infectious diseases.Mls-1 superantigen: molecular characterization and functional analysis.Signal transduction by microbial superantigens via MHC class II molecules.A 21-mer synthetic peptide of toxic shock syndrome toxin 1, TSST-1[58-78], activates T cells by binding to MHC class II and by an MHC unrestricted xenostimulatory pathway.Binding sites for bacterial and endogenous retroviral superantigens can be dissociated on major histocompatibility complex class II molecules.Characterization of human T cells reactive with the Mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against V beta 17, the T cell receptor gene product expressed by a large fraction of MAM-reactive human T cellImpact of MHC class I gene on resistance to murine AIDS.
P2860
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P2860
The alpha 1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
The alpha 1 domain of the HLA- ...... toxic shock syndrome toxin-1.
@en
type
label
The alpha 1 domain of the HLA- ...... toxic shock syndrome toxin-1.
@en
prefLabel
The alpha 1 domain of the HLA- ...... toxic shock syndrome toxin-1.
@en
P2093
P356
P1433
P1476
The alpha 1 domain of the HLA- ...... toxic shock syndrome toxin-1.
@en
P2093
P2888
P304
P356
10.1038/346474A0
P407
P577
1990-08-01T00:00:00Z
P6179
1036051208