Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.
about
Cancer vulnerabilities unveiled by genomic lossaxl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinaseProtein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.Charting the molecular network of the drug target Bcr-AblTLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis.Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinasesOverexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cellsTyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABLGeneration of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemiaLessons learned from the development of an abl tyrosine kinase inhibitor for chronic myelogenous leukemiaThe translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNAComprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomesMutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinaseMolecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activityRegulation of myeloid leukaemia by the cell-fate determinant MusashiTyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOSSelectivity and therapeutic inhibition of kinases: to be or not to be?Depletion of Pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 by Bcr-Abl promotes chronic myelogenous leukemia cell proliferation through continuous phosphorylation of Akt isoformsUbp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signalingTyrosine kinase - Role and significance in Cancer.The Philadelphia chromosome in leukemogenesisChronic myeloid leukemia: reminiscences and dreamsPhysiological and pathological implications of 5-hydroxymethylcytosine in diseasesMicroRNAs mediated regulation of MAPK signaling pathways in chronic myeloid leukemiaOncogenic kinase fusions: an evolving arena with innovative clinical opportunitiesA hostel for the hostile: the bone marrow niche in hematologic neoplasmsKinase-independent mechanisms of resistance of leukemia stem cells to tyrosine kinase inhibitorsSystems genetics for drug target discoveryCurrent concepts in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemiaSignal transduction in the chronic leukemias: implications for targeted therapiesAnimal models of leukemia: any closer to the real thing?A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domainCrystal Structures of ABL-Related Gene (ABL2) in Complex with Imatinib, Tozasertib (VX-680), and a Type I Inhibitor of the Triazole Carbothioamide ClassConformational Control Inhibition of the BCR-ABL1 Tyrosine Kinase, Including the Gatekeeper T315I Mutant, by the Switch-Control Inhibitor DCC-2036Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits LeukemogenesisNovel targeted therapies for Bcr-Abl positive acute leukemias: beyond STI571.Ponatinib in refractory Philadelphia chromosome-positive leukemias.Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE studyModeling of Chronic Myeloid Leukemia: An Overview of In Vivo Murine and Human Xenograft ModelsTransformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck
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P2860
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
1990年论文
@zh
1990年论文
@zh-cn
name
Induction of chronic myelogeno ...... f the Philadelphia chromosome.
@en
type
label
Induction of chronic myelogeno ...... f the Philadelphia chromosome.
@en
prefLabel
Induction of chronic myelogeno ...... f the Philadelphia chromosome.
@en
P2093
P356
P1433
P1476
Induction of chronic myelogeno ...... f the Philadelphia chromosome.
@en
P2093
D Baltimore
R A Van Etten
P304
P356
10.1126/SCIENCE.2406902
P407
P577
1990-02-01T00:00:00Z