Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis
about
Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1Sphingolipids as cell fate regulators in lung development and diseaseAll members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activityORMDL/serine palmitoyltransferase stoichiometry determines effects of ORMDL3 expression on sphingolipid biosynthesisLipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic TargetsFunctional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in miceHSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship.Promoter characterization and role of cAMP/PKA/CREB in the basal transcription of the mouse ORMDL3 geneExpression of the ORMDLS, modulators of serine palmitoyltransferase, is regulated by sphingolipids in mammalian cellsSphingolipid metabolites in inflammatory disease.Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificityORMDL orosomucoid-like proteins are degraded by free-cholesterol-loading-induced autophagy.A Conserved Circular Network of Coregulated Lipids Modulates Innate Immune Responses.Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in miceORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells.Airway reactivity and sphingolipids-implications for childhood asthmaGlycosphingolipids and cell death: one aim, many waysTopological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferaseHereditary sensory and autonomic neuropathy type 1 (HSANI) caused by a novel mutation in SPTLC2.17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.17q21 locus and ORMDL3: an increased risk for childhood asthma.Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.Intratracheal myriocin enhances allergen-induced Th2 inflammation and airway hyper-responsiveness.Coordinated regulation of the orosomucoid-like gene family expression controls de novo ceramide synthesis in mammalian cells.Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells.Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.Childhood asthma is associated with mutations and gene expression differences of ORMDL genes that can interact.ORMDL proteins regulate ceramide levels during sterile inflammation.Sphingolipid metabolic flow controls phosphoinositide turnover at the trans-Golgi network.Sphingolipid metabolism in cancer signalling and therapy.Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity.Ceramide species are elevated in human breast cancer and are associated with less aggressiveness.
P2860
Q27933657-4F055F36-F605-48FE-A51A-AE4B0AF0C990Q28084945-400C5101-8FAF-475E-9D03-714D9CC3250DQ28117543-9C864C24-F09F-459C-8982-960494187BC0Q28118152-7D3AD44A-A814-4809-B6FC-F3E59F7B111DQ28276574-76BC8463-3B43-49AD-8A61-780AE945C45EQ28506403-F645DAE0-F0E1-449C-B0AF-FE5B65BABCC6Q30382642-CA772B7A-F152-4DC4-97F4-1E0DCF6E94DCQ34663879-1B80CD8D-E23E-4F57-943C-C4750DACD119Q34801792-9762D8D9-39ED-477D-A605-5A008386F721Q35061720-618DB22A-E86A-4C02-97D7-21BA7AD91404Q35079758-28A0A37F-6217-4240-8067-C04F0363F71EQ35229446-6E04DCF6-0BA9-4418-922C-F7A9A478F132Q35912807-F11539F7-59FF-4D9E-B8F8-E8FA11D63D4EQ36113177-F0C63903-137E-4ADF-94A8-8935DB42CF31Q36316945-153ACEE6-7106-4315-B1B4-908B42815E77Q36348432-4D2BDAEC-0FF0-49E5-A9CB-6831786CC857Q36405917-D6BABA19-6541-485F-9B75-6C047DEB36A0Q36742139-2CF31E42-789B-44F5-92F5-63675038E58BQ37027169-CB254300-8C08-423B-BDDC-33613211BD20Q37423775-407DCD50-AF65-4E75-B840-E52604B8A1BCQ38156023-D5DE96EB-708C-4DBE-AD7F-8B24649BA5A2Q38266425-D771FC03-8EC5-4B9D-8EDB-F273630BE202Q38690945-2B7F93AF-EAD5-46C5-946F-383DE58CA09FQ38771128-0EA41D79-E700-4019-8212-F67A3A92DF68Q38821886-1E372B65-80EA-482C-AE7C-0EC7A9DCB3C4Q38927559-936EBA6C-BE65-4AFE-87ED-FFAA96BACB01Q40500249-8CD9C755-94B5-4AAC-A1CE-657359652F40Q41648516-B1637E1A-3E78-46A4-B8C3-DE99160EE7D0Q41716771-53B6D16C-C048-4FC8-8595-E8E1C098AFBFQ42159911-54D57385-572A-450F-A20C-54FF0922EEE7Q48156182-CD83B2A3-3884-412C-B51F-4EAB1CBE790BQ49950035-304596B2-0703-404B-9CB7-C222032FEB16Q50969955-BE516625-D1A9-48EA-87B9-208BE8A54B2AQ55002300-8D4221AF-C791-4659-9115-17FEFE8F8C1D
P2860
Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis
@en
type
label
Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis
@en
prefLabel
Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis
@en
P2860
P356
P1476
Mammalian ORMDL proteins mediate the feedback response in ceramide biosynthesis
@en
P2093
Binks W Wattenberg
Deanna L Siow
P2860
P304
40198-40204
P356
10.1074/JBC.C112.404012
P407
P577
2012-10-12T00:00:00Z