Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities.
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Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valvesFunctional Analysis of Two Novel Mutations in TWIST1 Protein Motifs Found in Ventricular Septal Defect PatientsPhosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodelingAn absence of Twist1 results in aberrant cardiac neural crest morphogenesisDestabilization of the TWIST1/E12 complex dimerization following the R154P point-mutation of TWIST1: an in silico approach.Timed deletion of Twist1 in the limb bud reveals age-specific impacts on autopod and zeugopod patterningAn amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells.Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valvesAnalysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivativesGenome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells.Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis.Cryptochromes Interact Directly with PIFs to Control Plant Growth in Limiting Blue Light.Redundant or separate entities?--roles of Twist1 and Twist2 as molecular switches during gene transcriptionTwist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crestPhosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasivenessStructure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cellsCritical role for TWIST1 in the induction of human uterine decidualization.A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis.FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung BranchingThe Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial CellsTwist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closureDeciphering the molecular mechanisms underlying the binding of the TWIST1/E12 complex to regulatory E-box sequences.Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap.Phosphoregulation of Twist1 provides a mechanism of cell fate control.A twist of insight - the role of Twist-family bHLH factors in development.Interhelical loops within the bHLH domain are determinant in maintaining TWIST1-DNA complexes.Invasive prostate cancer cells are tumor initiating cells that have a stem cell-like genomic signature.Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells.A bHLH code for cardiac morphogenesis.Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defectsTwist factor regulation of non-cardiomyocyte cell lineages in the developing heart.The molecular basis of human congenital limb malformations.Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.Identification of spontaneous mutations within the long-range limb-specific Sonic hedgehog enhancer (ZRS) that alter Sonic hedgehog expression in the chicken limb mutants oligozeugodactyly and silkie breed.Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb.Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.Twist1 activity thresholds define multiple functions in limb development.Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium.The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice.
P2860
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P2860
Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Mutations within helix I of Tw ...... ion of DNA binding affinities.
@en
type
label
Mutations within helix I of Tw ...... ion of DNA binding affinities.
@en
prefLabel
Mutations within helix I of Tw ...... ion of DNA binding affinities.
@en
P2093
P2860
P356
P1476
Mutations within helix I of Tw ...... ion of DNA binding affinities.
@en
P2093
Anthony B Firulli
Beth A Firulli
Bradley A Redick
Simon J Conway
P2860
P304
27536-27546
P356
10.1074/JBC.M702613200
P407
P577
2007-07-25T00:00:00Z