The NusA N-terminal domain is necessary and sufficient for enhancement of transcriptional pausing via interaction with the RNA exit channel of RNA polymerase.
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Termination and antitermination: RNA polymerase runs a stop signInsights into the Regulatory Landscape of the Lysine RiboswitchRoles for the transcription elongation factor NusA in both DNA repair and damage tolerance pathways in Escherichia coliRNA polymerase pausing and nascent-RNA structure formation are linked through clamp-domain movementArchitecture of a transcribing-translating expressome.NusA interaction with the α subunit of E. coli RNA polymerase is via the UP element site and releases autoinhibitionDistinct pathways of RNA polymerase regulation by a phage-encoded factor.RNA polymerase-induced remodelling of NusA produces a pause enhancement complex.Comparative proteome analysis of Helicobacter pylori clinical strains by two-dimensional gel electrophoresis.Bacterial RNA polymerase can retain σ70 throughout transcription.A novel phage-encoded transcription antiterminator acts by suppressing bacterial RNA polymerase pausingRho-dependent transcription termination is essential to prevent excessive genome-wide R-loops in Escherichia coli.Bacterial Transcription as a Target for Antibacterial Drug Development.TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycleA Two-Way Street: Regulatory Interplay between RNA Polymerase and Nascent RNA Structure.Nascent RNA length dictates opposing effects of NusA on antitermination.Transcription is regulated by NusA:NusG interaction.Antisense oligonucleotide-stimulated transcriptional pausing reveals RNA exit channel specificity of RNA polymerase and mechanistic contributions of NusA and RfaH.CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase.NusA-dependent transcription termination prevents misregulation of global gene expression.Mycobacterial RNA polymerase requires a U-tract at intrinsic terminators and is aided by NusG at suboptimal terminators.Unravelling the means to an end: RNA polymerase II transcription termination.In-Culture Cross-Linking of Bacterial Cells Reveals Large-Scale Dynamic Protein-Protein Interactions at the Peptide LevelThe role of E. coli Nus-factors in transcription regulation and transcription:translation coupling: From structure to mechanism.Regulation of transcription elongation and termination.Regulation of Transcript Elongation.Compromised factor-dependent transcription termination in a nusA mutant of Escherichia coli: spectrum of termination efficiencies generated by perturbations of Rho, NusG, NusA, and H-NS family proteins.Applied force provides insight into transcriptional pausing and its modulation by transcription factor NusA.The RPB2 flap loop of human RNA polymerase II is dispensable for transcription initiation and elongation.Transcription Elongation Factor NusA Is a General Antagonist of Rho-dependent Termination in Escherichia coli.Cys-pair reporters detect a constrained trigger loop in a paused RNA polymerase.N protein from lambdoid phages transforms NusA into an antiterminator by modulating NusA-RNA polymerase flap domain interactions.Structural basis for λN-dependent processive transcription antitermination.The interaction surface of a bacterial transcription elongation factor required for complex formation with an antiterminator during transcription antitermination.Alterations in the β flap and β' dock domains of the RNA polymerase abolish NusA-mediated feedback regulation of the metY-nusA-infB operon.Determination of RNA polymerase binding surfaces of transcription factors by NMR spectroscopy.Transcriptional precision and accuracy in development: from measurements to models and mechanisms.Gfh factors and NusA cooperate to stimulate transcriptional pausing and termination.In Vitro Transcription Assays and Their Application in Drug Discovery.Experimental evolution of diverse Escherichia coli metabolic mutants identifies genetic loci for convergent adaptation of growth rate.
P2860
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P2860
The NusA N-terminal domain is necessary and sufficient for enhancement of transcriptional pausing via interaction with the RNA exit channel of RNA polymerase.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The NusA N-terminal domain is ...... xit channel of RNA polymerase.
@en
type
label
The NusA N-terminal domain is ...... xit channel of RNA polymerase.
@en
prefLabel
The NusA N-terminal domain is ...... xit channel of RNA polymerase.
@en
P2093
P2860
P1476
The NusA N-terminal domain is ...... xit channel of RNA polymerase.
@en
P2093
Dmitry G Vassylyev
Innokenti Toulokhonov
Kook Sun Ha
Robert Landick
P2860
P304
P356
10.1016/J.JMB.2010.06.036
P407
P577
2010-06-25T00:00:00Z