Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing
about
Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions.Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin.Reactivity of Nucleic Acid Radicals.Quantitative detection of 8-Oxo-7,8-dihydro-2'-deoxyguanosine using chemical tagging and qPCRNanopore detection of 8-oxoguanine in the human telomere repeat sequence.Spirodi(iminohydantoin) products from oxidation of 2'-deoxyguanosine in the presence of NH4Cl in nucleoside and oligodeoxynucleotide contexts.5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA ContextsBase and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA.Identification of DNA lesions using a third base pair for amplification and nanopore sequencing.pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion.Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair.Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA.Pyrimidine base damage is increased in women with BRCA mutations.Structural destabilization of DNA duplexes containing single-base lesions investigated by nanopore measurementsRepair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry.Mapping structurally defined guanine oxidation products along DNA duplexes: influence of local sequence context and endogenous cytosine methylationReverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers.The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable LiabilityRemoval of oxidatively generated DNA damage by overlapping repair pathways.Formation and processing of DNA damage substrates for the hNEIL enzymes.Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products.The R- and S-diastereoisomeric effects on the guanidinohydantoin-induced mutations in DNA.G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA.Biophysical properties and thermal stability of oligonucleotides of RNA containing 7,8-dihydro-8-hydroxyadenosine.Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel.Simulation of oxidative stress of guanosine and 8-oxo-7,8-dihydroguanosine by electrochemically assisted injection-capillary electrophoresis-mass spectrometry.In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA.Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch.Conformational stabilities of iminoallantoin and its base pairs in DNA: implications for mutagenicity.
P2860
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P2860
Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Structural context effects in ...... ase stacking, and base pairing
@en
type
label
Structural context effects in ...... ase stacking, and base pairing
@en
prefLabel
Structural context effects in ...... ase stacking, and base pairing
@en
P2093
P2860
P356
P1476
Structural context effects in ...... ase stacking, and base pairing
@en
P2093
Aaron M Fleming
Adrienne C Dlouhy
Cynthia J Burrows
James G Muller
P2860
P304
15091-15102
P356
10.1021/JA306077B
P407
P577
2012-08-29T00:00:00Z