The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids.
about
Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapyMammalian P4-ATPases and ABC transporters and their role in phospholipid transportDisrupting P-glycoprotein function in clinical settings: what can we learn from the fundamental aspects of this transporter?Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion developmentCLN3p impacts galactosylceramide transport, raft morphology, and lipid contentP(5A)-type ATPase Cta4p is essential for Ca2+ transport in the endoplasmic reticulum of Schizosaccharomyces pombeProteins that bind and move lipids: MsbA and NPC1.ABC drug transporter expression and functional activity in trophoblast-like cell lines and differentiating primary trophoblast.P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors.The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sitesThe DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificityCeramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.Multi-system disorders of glycosphingolipid and ganglioside metabolismThe association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effectImino sugar inhibitors for treating the lysosomal glycosphingolipidoses.ABC multidrug transporters: structure, function and role in chemoresistance.P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells.Reconstitution of glucosylceramide flip-flop across endoplasmic reticulum: implications for mechanism of glycosphingolipid biosynthesis.Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cellsCandida drug resistance protein 1, a major multidrug ATP binding cassette transporter of Candida albicans, translocates fluorescent phospholipids in a reconstituted system.Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pumpOn the origin of large flexibility of P-glycoprotein in the inward-facing stateLactosylceramide: a lipid second messenger in neuroinflammatory disease.Reconstitution of phospholipid translocase activity with purified Drs2p, a type-IV P-type ATPase from budding yeast.Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.Glycosphingolipid storage in Fabry mice extends beyond globotriaosylceramide and is affected by ABCB1 depletion.Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function.Glycosphingolipids--nature, function, and pharmacological modulation.Glycosphingolipid functionsFlipping and flopping--lipids on the move.Lipid transport by mammalian ABC proteins.The role of sphingolipids in drug metabolism and transport.Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins.P-glycoprotein and membrane roles in multidrug resistance.Synthesis of a novel photoactivatable glucosylceramide cross-linker.Lipids regulate the hydrolysis of membrane bound glucosylceramide by lysosomal β-glucocerebrosidase.Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein.Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?ABCB1 protects kidney proximal tubule cells against cadmium-induced apoptosis: roles of cadmium and ceramide transport.Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches.
P2860
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P2860
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
The reconstituted P-glycoprote ...... her simple glycosphingolipids.
@en
type
label
The reconstituted P-glycoprote ...... her simple glycosphingolipids.
@en
prefLabel
The reconstituted P-glycoprote ...... her simple glycosphingolipids.
@en
P2860
P356
P1433
P1476
The reconstituted P-glycoprote ...... her simple glycosphingolipids.
@en
P2093
Paul D W Eckford
P2860
P304
P356
10.1042/BJ20050047
P407
P577
2005-07-01T00:00:00Z