Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
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The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosisMammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growthGLO1 overexpression in human malignant melanomaTherapeutic Implications of Targeting AKT Signaling in MelanomaRedox-directed cancer therapeutics: molecular mechanisms and opportunitiesThe cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growthMechanisms of superoxide signaling in epigenetic processes: relation to aging and cancerTargeting NADPH oxidases for the treatment of cancer and inflammationMelanocytes as instigators and victims of oxidative stressNUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.Melanoma Brain Metastasis: Mechanisms, Models, and MedicineFyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migrationNADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromiumRegulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue.Antitumor agent 25-epi Ritterostatin GN1N induces endoplasmic reticulum stress and autophagy mediated cell death in melanoma cellsAKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1).NADPH oxidases in vascular pathology.Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation.Current approaches to the treatment of metastatic brain tumours.NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells.Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen speciesCytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survivalAkt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells.Inhibitory effects of Lang-du extract on the in vitro and in vivo growth of melanoma cells and its molecular mechanisms of action.Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.Updates of reactive oxygen species in melanoma etiology and progression.NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phoxRedox signaling in cardiac myocytes.Vertical targeting of the phosphatidylinositol-3 kinase pathway as a strategy for treating melanoma.Melanoma genotypes and phenotypes get personal.Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB.RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10,c12-conjugated linoleic acid isomer on A375 melanoma cells.Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathwaysThe T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis.Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levelsIn vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cellsMelanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.PHIPing out: a genetic basis for tumor ulceration.Phosphatidylinositol-3-kinase as a therapeutic target in melanomaAn extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.
P2860
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P2860
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
@en
type
label
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
@en
prefLabel
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.
@en
P2093
P2860
P50
P356
P1476
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
@en
P2093
Baskaran Govindarajan
Bethaney J Vincent
Brian J Nickoloff
Cynthia Cohen
J David Lambeth
Jack L Arbiser
James E Sligh
Jan A Smeitink
Jeffrey A Canter
José M Cuezva
P2860
P304
P356
10.1172/JCI30102
P407
P577
2007-02-22T00:00:00Z