Overexpression of Akt converts radial growth melanoma to vertical growth melanoma. - Wikidata - wikimedia - TriplyDB

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

http://www.wikidata.org/entity/Q41825555

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The redox antimalarial dihydroartemisinin targets human metastatic melanoma cells but not primary melanocytes with induction of NOXA-dependent apoptosis Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth GLO1 overexpression in human malignant melanoma Therapeutic Implications of Targeting AKT Signaling in Melanoma Redox-directed cancer therapeutics: molecular mechanisms and opportunities The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth Mechanisms of superoxide signaling in epigenetic processes: relation to aging and cancer Targeting NADPH oxidases for the treatment of cancer and inflammation Melanocytes as instigators and victims of oxidative stress NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.Melanoma Brain Metastasis: Mechanisms, Models, and Medicine Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium Regulation of NADPH-dependent Nitric Oxide and reactive oxygen species signalling in endothelial and melanoma cells by a photoactive NADPH analogue.Antitumor agent 25-epi Ritterostatin GN1N induces endoplasmic reticulum stress and autophagy mediated cell death in melanoma cells AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1).NADPH oxidases in vascular pathology.Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation.Current approaches to the treatment of metastatic brain tumours.NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells.Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival Akt3-mediated resistance to apoptosis in B-RAF-targeted melanoma cells.Inhibitory effects of Lang-du extract on the in vitro and in vivo growth of melanoma cells and its molecular mechanisms of action.Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.Updates of reactive oxygen species in melanoma etiology and progression.NADPH oxidase activation in pancreatic cancer cells is mediated through Akt-dependent up-regulation of p22phox Redox signaling in cardiac myocytes.Vertical targeting of the phosphatidylinositol-3 kinase pathway as a strategy for treating melanoma.Melanoma genotypes and phenotypes get personal.Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB.RedOx status, proteasome and APEH: insights into anticancer mechanisms of t10,c12-conjugated linoleic acid isomer on A375 melanoma cells.Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis.Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells Melanoma chemoprevention in skin reconstructs and mouse xenografts using isoselenocyanate-4.PHIPing out: a genetic basis for tumor ulceration.Phosphatidylinositol-3-kinase as a therapeutic target in melanoma An extracellular signal-regulated kinase 2 survival pathway mediates resistance of human mesothelioma cells to asbestos-induced injury.

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P2860

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

http://www.wikidata.org/entity/Q41825555

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

@en

type

label

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

@en

prefLabel

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

@en

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Journal of Clinical Investigation

P1476

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma

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P2093

Baskaran Govindarajan

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Bethaney J Vincent

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Brian J Nickoloff

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Cynthia Cohen

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J David Lambeth

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Jack L Arbiser

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James E Sligh

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Jan A Smeitink

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Jeffrey A Canter

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José M Cuezva

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Protein measurement with the Folin phenol reagent

Cell transformation by the superoxide-generating oxidase Mox1

Identification of renox, an NAD(P)H oxidase in kidney

Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1

Negative control of p53 by Sir2alpha promotes cell survival under stress

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Reactive oxygen generated by Nox1 triggers the angiogenic switch

Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis

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719-729

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10.1172/JCI30102

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3

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117

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Richard J Rodenburg

Kathy K. Griendling

Marta Martínez-Díez

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2007-02-22T00:00:00Z

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6488444

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17318262

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