P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements.
about
Block of sodium channels by divalent mercury: role of specific cysteinyl residues in the P-loop region.A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channelSolvent effects on squid sodium channels are attributable to movements of a flexible protein structure in gating currents and to hydration in a pore.Epithelial sodium channel pore region. structure and role in gating.Structure and function of voltage-gated sodium channels.Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor.Charged residues between the selectivity filter and S6 segments contribute to the permeation phenotype of the sodium channel.Interaction between the pore and a fast gate of the cardiac sodium channel.A structural rearrangement in the sodium channel pore linked to slow inactivation and use dependence.mu-conotoxin GIIIA interactions with the voltage-gated Na(+) channel predict a clockwise arrangement of the domains.Block of tetrodotoxin-resistant Na+ channel pore by multivalent cations: gating modification and Na+ flow dependence.Immobilizing the moving parts of voltage-gated ion channelsMolecular architecture of the voltage-dependent Na channel: functional evidence for alpha helices in the pore.Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin.Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures.State-dependent accessibility of the P-S6 linker of pacemaker (HCN) channels supports a dynamic pore-to-gate coupling model.Metal bridges to probe membrane ion channel structure and function.Mechanisms of cation permeation in cardiac sodium channel: description by dynamic pore model.Determinants of Cation Permeation and Drug Sensitivity in Predicted Transmembrane Helix 9 and Adjoining Exofacial Re-entrant Loop 5 of Na+/H+ Exchanger NHE1.Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels.Sodium channels: ionic model of slow inactivation and state-dependent drug binding.Dynamic changes in the TRPA1 selectivity filter lead to progressive but reversible pore dilation.The selectivity filter of the voltage-gated sodium channel is involved in channel activation.An external determinant in the S5-P linker of the pacemaker (HCN) channel identified by sulfhydryl modification.Interaction of a dinoflagellate neurotoxin with voltage-activated ion channels in a marine diatom.
P2860
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P2860
P-loop flexibility in Na+ channel pores revealed by single- and double-cysteine replacements.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
P-loop flexibility in Na+ chan ...... double-cysteine replacements.
@en
type
label
P-loop flexibility in Na+ chan ...... double-cysteine replacements.
@en
prefLabel
P-loop flexibility in Na+ chan ...... double-cysteine replacements.
@en
P2093
P2860
P356
P1476
P-loop flexibility in Na+ chan ...... double-cysteine replacements.
@en
P2093
P2860
P356
10.1085/JGP.110.1.59
P577
1997-07-01T00:00:00Z