C/EBPalpha or C/EBPalpha oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-kappaB p50 bound to the bcl-2 and FLIP gene promoters.
about
C/EBPα Dysregulation in AML and ALLAberrant nuclear factor-kappa B activity in acute myeloid leukemia: from molecular pathogenesis to therapeutic targetInvolvement of NF-kappaB activation in the apoptosis induced by extracellular adenosine in human hepatocellular carcinoma HepG2 cells.Bcl3 prevents acute inflammatory lung injury in mice by restraining emergency granulopoiesis.Bortezomib induces nuclear translocation of IκBα resulting in gene-specific suppression of NF-κB--dependent transcription and induction of apoptosis in CTCL.C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes.SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesisCCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinomaAP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcriptionC/EBPα, C/EBPα oncoproteins, or C/EBPβ preferentially bind NF-κB p50 compared with p65, focusing therapeutic targeting on the C/EBP:p50 interaction.In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.HTLV-1 bZIP factor supports proliferation of adult T cell leukemia cells through suppression of C/EBPα signalingThe significance of c.690G>T polymorphism (rs34529039) and expression of the CEBPA gene in ovarian cancer outcome.B-cell precursor acute lymphoblastic leukemia with isolated t(14;19)(q32;q13) abnormality involving the CEBPG gene.C/EBPα in normal and malignant myelopoiesis.Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis.Long non-coding RNA CEBPA-AS1 correlates with poor prognosis and promotes tumorigenesis via CEBPA/Bcl2 in oral squamous cell carcinoma.NF-κB in Hematological Malignancies.Inhibition of Casein Kinase 2 Disrupts Differentiation of Myeloid Cells in Cancer and Enhances the Efficacy of Immunotherapy in Mice
P2860
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P2860
C/EBPalpha or C/EBPalpha oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-kappaB p50 bound to the bcl-2 and FLIP gene promoters.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
C/EBPalpha or C/EBPalpha oncop ...... bcl-2 and FLIP gene promoters.
@en
type
label
C/EBPalpha or C/EBPalpha oncop ...... bcl-2 and FLIP gene promoters.
@en
prefLabel
C/EBPalpha or C/EBPalpha oncop ...... bcl-2 and FLIP gene promoters.
@en
P2093
P2860
P356
P1433
P1476
C/EBPalpha or C/EBPalpha oncop ...... bcl-2 and FLIP gene promoters.
@en
P2093
A D Friedman
A K Ghosal
I Paz-Priel
P2860
P2888
P304
P356
10.1038/LEU.2008.297
P577
2008-11-06T00:00:00Z
P5875
P6179
1015392050