Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage.
about
An Ancient Fingerprint Indicates the Common Ancestry of Rossmann-Fold Enzymes Utilizing Different Ribose-Based CofactorsEnzyme promiscuity: engine of evolutionary innovation.Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis.Fidelity index determination of DNA methyltransferases.Correlated occurrence and bypass of frame-shifting insertion-deletions (InDels) to give functional proteins.Substrate scope and selectivity in offspring to an enzyme subjected to directed evolution.Directed evolution of improved zinc finger methyltransferases.Evolution of DNA specificity in a transcription factor family produced a new gene regulatory moduleSystematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral MutationsFunctional Trade-Offs in Promiscuous Enzymes Cannot Be Explained by Intrinsic Mutational Robustness of the Native ActivityEngineering and Directed Evolution of DNA Methyltransferases.Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.Modulating protein stability - directed evolution strategies for improved protein function.Dynamics and constraints of enzyme evolution.Increasing cleavage specificity and activity of restriction endonuclease KpnI.Editorial: Evolution acting on the same target, but at multiple levels: Proteins as the test case.Isospecific adenine DNA methyltransferases show distinct preferences towards DNA substrates.Protein design: from computer models to artificial intelligence
P2860
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P2860
Evolutionary transitions to new DNA methyltransferases through target site expansion and shrinkage.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Evolutionary transitions to ne ...... site expansion and shrinkage.
@en
type
label
Evolutionary transitions to ne ...... site expansion and shrinkage.
@en
prefLabel
Evolutionary transitions to ne ...... site expansion and shrinkage.
@en
P2860
P356
P1476
Evolutionary transitions to ne ...... site expansion and shrinkage.
@en
P2093
Dan S Tawfik
Liat Rockah-Shmuel
P2860
P304
11627-11637
P356
10.1093/NAR/GKS944
P577
2012-10-15T00:00:00Z