A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases.
about
Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular diseaseAn Omics Perspective on Molecular Biomarkers for Diagnosis, Prognosis, and Therapeutics of CholangiocarcinomaPattern Recognition Receptors in Cancer Progression and Metastasis'Acute myeloid leukemia: a comprehensive review and 2016 update'The natural chemopreventive agent sulforaphane inhibits STAT5 activity2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway.The synthetic α-bromo-2',3,4,4'-tetramethoxychalcone (α-Br-TMC) inhibits the JAK/STAT signaling pathway.The Chemopreventive Phytochemical Moringin Isolated from Moringa oleifera Seeds Inhibits JAK/STAT Signaling.Multiple regulation pathways and pivotal biological functions of STAT3 in cancer.Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis.Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancyClinical value of monoclonal antibodies and tyrosine kinase inhibitors in the treatment of head and neck squamous cell carcinoma.STAT3 inhibitors: finding a home in lymphoma and leukemia.Targeting novel signaling pathways for resistant acute myeloid leukemia.From physiology to disease and targeted therapy: interleukin-6 in inflammation and inflammation-associated carcinogenesis.Investigational therapies targeting signal transducer and activator of transcription 3 for the treatment of cancer.Targeting non-receptor tyrosine kinases using small molecule inhibitors: an overview of recent advances.A STAT inhibitor patent review: progress since 2011.Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt.The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations.Novel STAT 3 inhibitors for treating gastric cancer.FLT3-ITD confers resistance to the PI3K/Akt pathway inhibitors by protecting the mTOR/4EBP1/Mcl-1 pathway through STAT5 activation in acute myeloid leukemiaHitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)Novel carbazole inhibits phospho-STAT3 through induction of protein-tyrosine phosphatase PTPN6.The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells.Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling.Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3.Suppression of Breast Cancer Cell Proliferation by Selective Single-Domain Antibody for Intracellular STAT3.Mutations in the signal transducer and activator of transcription family of genes in cancer.Phloridzin docosahexaenoate, a novel flavonoid derivative, suppresses growth and induces apoptosis in T-cell acute lymphoblastic leukemia cells.Targeting the IL-6/JAK/STAT3 signalling axis in cancer.A First-in-Human Phase 1 Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers.Phase 1 and pharmacological trial of OPB-31121, a signal transducer and activator of transcription-3 inhibitor, in patients with advanced hepatocellular carcinoma.
P2860
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P2860
A novel STAT inhibitor, OPB-31121, has a significant antitumor effect on leukemia with STAT-addictive oncokinases.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
A novel STAT inhibitor, OPB-31 ...... th STAT-addictive oncokinases.
@en
type
label
A novel STAT inhibitor, OPB-31 ...... th STAT-addictive oncokinases.
@en
prefLabel
A novel STAT inhibitor, OPB-31 ...... th STAT-addictive oncokinases.
@en
P2093
P2860
P356
P1433
P1476
A novel STAT inhibitor, OPB-31 ...... th STAT-addictive oncokinases.
@en
P2093
F Hayakawa
K Sugimoto
N Hashimoto
S Kurahashi
P2860
P2888
P356
10.1038/BCJ.2013.63
P577
2013-11-29T00:00:00Z
P5875
P6179
1016605569