Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection.
about
Molecular and cellular insights into T cell exhaustionOvercoming T cell exhaustion in infection and cancerUsing epigenetics to define vaccine-induced memory T cellsMolecular mechanisms of T cell co-stimulation and co-inhibitionCMV-Specific CD8 T Cell Differentiation and Localization: Implications for Adoptive TherapiesInnate and Adaptive Immune Regulation During Chronic Viral InfectionsLoss of the death receptor CD95 (Fas) expression by dendritic cells protects from a chronic viral infection.Autoimmune effector memory T cells: the bad and the goodAberrant plasma IL-7 and soluble IL-7 receptor levels indicate impaired T-cell response to IL-7 in human tuberculosis.Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade.Augmented replicative capacity of the boosting antigen improves the protective efficacy of heterologous prime-boost vaccine regimens.Alarmin IL-33 acts as an immunoadjuvant to enhance antigen-specific tumor immunityThe transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infectionEnhanced CD8 T cell responses through GITR-mediated costimulation resolve chronic viral infection.Molecular regulation of effector and memory T cell differentiationT cell exhaustion during persistent viral infections.Epigenetic manipulation restores functions of defective CD8⁺ T cells from chronic viral infectionMemory CD8 T cell transcriptional plasticity.Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge modelImpaired Subset Progression and Polyfunctionality of T Cells in Mice Exposed to Methamphetamine during Chronic LCMV Infection.Shortened Intervals during Heterologous Boosting Preserve Memory CD8 T Cell Function but Compromise LongevityUbiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity.Costimulatory and Coinhibitory Receptor Pathways in Infectious DiseaseCutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory.Immediate Dysfunction of Vaccine-Elicited CD8+ T Cells Primed in the Absence of CD4+ T Cells.High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survivalDemethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion.IL2Rβ-dependent signals drive terminal exhaustion and suppress memory development during chronic viral infection.Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness.OMIP-036: Co-inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets.PD-1 coinhibitory signals: the link between pathogenesis and protection.Tolerance and exhaustion: defining mechanisms of T cell dysfunction.De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation.Human T Cell Memory: A Dynamic ViewCell-Intrinsic Barriers of T Cell-Based Immunotherapy.T cell exhaustion: from pathophysiological basics to tumor immunotherapy.Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection.Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.
P2860
Q26800047-C57C40BF-CE8F-4F8F-B5AF-DF2F625DC053Q26829885-251BB8FD-CA13-4E72-9D06-C97034DD1F35Q26849423-D0C787B2-4FC7-4194-989B-F03E04A8B735Q26864888-E1452724-C584-40F7-9E9E-104B9438FB41Q28073770-89D1E4C5-50CA-450D-9B70-E95B489DED5EQ28079717-FFB9569F-C4A6-4324-8C7B-FE609A87CFD3Q33767444-64970337-6B49-4056-A461-3CB1233AB299Q33794691-FB2F5134-FCD7-4915-B56E-6A6AF0C2DD69Q33803416-DEE563F1-99D2-46B2-B5D0-40FC5B4A5F03Q33835454-25004FCA-6176-4D1D-8AB6-F7CE360AF84BQ33887812-910277DD-5E52-408A-912E-0712BBB3A8ADQ34033407-A11C34EE-A670-4CF5-9399-1E7EE003DC45Q34734469-BB46E964-1650-4EF5-B00F-42F52C52CD46Q35147454-CBC50E85-39D6-4ABF-97E7-D2FEECCC1287Q35283304-0B756CD9-8302-4FDD-B481-503DB807333FQ35582265-15D6DD26-5F65-4CEA-A2B6-DBC8B2AB1C1EQ35618602-810E8966-7356-47B4-825B-6C76E067C01DQ35659317-970D2570-F09A-48AE-A0D4-DA2DFC2C5863Q35988587-72F7AB7B-E5CC-4385-B5E4-A9E4124C0C8FQ36168052-9370DA65-D947-4321-8AD5-1785066E43B1Q36706188-A973B0C9-2813-42A4-92A8-DFFB44697A03Q36757129-57670699-D84B-4154-9184-807F596F8531Q36919711-986D81DD-17A5-4FFE-890A-D62767E996C3Q36986131-839B29B6-D5FA-44BE-9C4D-8F157E315333Q37110140-404D8B12-224D-4242-B553-CD3BD3163605Q37189696-5F345902-0C46-4974-9C01-C4E617C9911DQ37197889-D1F4CE2A-DA34-4EA2-AB9F-10FF9994B4A6Q37252876-8B7B88AE-C102-4A57-B89E-C632F13F44EBQ37264094-31653AA8-79EA-422C-A258-C7336C8E1DC1Q37280990-08F1D6FA-3F64-48E6-A077-8512584E5FCCQ37527942-FCB69D90-19AE-497F-AD09-2BA02B2560B2Q37732151-C61436A5-34EB-487C-9EFD-0E9B7E1BBFF5Q38095246-CB5C6A22-DB17-498C-AADA-B78FF08D3C74Q38161101-79D4ABCF-5112-4161-9B51-88C6F975E9A5Q38709894-ECF583B5-56B1-42DD-AB79-04D75B4B681EQ38761049-1D874C01-0D16-4866-9883-A9A8F9E6498BQ39003162-B984BA8D-E7BC-44AB-8D92-667F456952F0Q39078341-9C55580C-BBAA-41A6-8D8A-2E8B554D2ED1Q39231572-48A4D3E9-EFC7-4CDC-8559-E82AB40B70D5Q39518055-66BBF137-E0CF-4D0E-8E1F-40FFF36992DE
P2860
Progressive loss of memory T cell potential and commitment to exhaustion during chronic viral infection.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Progressive loss of memory T c ...... uring chronic viral infection.
@en
type
label
Progressive loss of memory T c ...... uring chronic viral infection.
@en
prefLabel
Progressive loss of memory T c ...... uring chronic viral infection.
@en
P2093
P2860
P356
P1433
P1476
Progressive loss of memory T c ...... during chronic viral infection
@en
P2093
E John Wherry
Jill M Angelosanto
Shawn D Blackburn
P2860
P304
P356
10.1128/JVI.00889-12
P407
P577
2012-05-23T00:00:00Z