Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.
about
Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomicsMST kinases in development and diseaseConcepts in solid tumor evolutionAneuploidy-induced cellular stresses limit autophagic degradation.Mutational landscape of aggressive cutaneous squamous cell carcinomaAbnormal dosage of ultraconserved elements is highly disfavored in healthy cells but not cancer cellsA Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer TypesHuman Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell LinesTargeting the adaptability of heterogeneous aneuploidsFunctional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells.Unraveling the clonal hierarchy of somatic genomic aberrations.Bioinformatics: Big data versus the big C.Statistically identifying tumor suppressors and oncogenes from pan-cancer genome-sequencing dataDeletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma.Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions.DOTS-Finder: a comprehensive tool for assessing driver genes in cancer genomes.HBx protein-mediated ATOH1 downregulation suppresses ARID2 expression and promotes hepatocellular carcinoma.The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters.The Hippo pathway in disease and therapy: cancer and beyondOncodriveROLE classifies cancer driver genes in loss of function and activating mode of actionThe BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.Expanding the computational toolbox for mining cancer genomes.Single cell sequencing reveals low levels of aneuploidy across mammalian tissues.Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach.Chromosome rearrangements via template switching between diverged repeated sequences.Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.Role of non-coding sequence variants in cancer.Only three driver gene mutations are required for the development of lung and colorectal cancers.Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism.Recurrent point mutations in the kinetochore gene KNSTRN in cutaneous squamous cell carcinoma.ICan: an integrated co-alteration network to identify ovarian cancer-related genesThe fitness consequences of aneuploidy are driven by condition-dependent gene effects.Aneuploidy and chromosomal instability in cancer: a jackpot to chaos.Oncogenes and tumor suppressor genes: comparative genomics and network perspectives.Bioinformatics analysis of thousands of TCGA tumors to determine the involvement of epigenetic regulators in human cancer.Computational methods and resources for the interpretation of genomic variants in cancerMobile element insertions are frequent in oesophageal adenocarcinomas and can mislead paired-end sequencing analysis.Loss of heterozygosity: what is it good for?
P2860
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P2860
Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Cumulative haploinsufficiency ...... s and shape the cancer genome.
@en
type
label
Cumulative haploinsufficiency ...... s and shape the cancer genome.
@en
prefLabel
Cumulative haploinsufficiency ...... s and shape the cancer genome.
@en
P2093
P2860
P1433
P1476
Cumulative haploinsufficiency ...... s and shape the cancer genome.
@en
P2093
Andrew Wei Xu
John C Yoon
Kristen E Mengwasser
Laura M Sack
Peter J Park
Stephen J Elledge
P2860
P304
P356
10.1016/J.CELL.2013.10.011
P407
P577
2013-10-31T00:00:00Z