about
IgH chain class switch recombination: mechanism and regulationDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationDeletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctionsRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsReduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymesApurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.Apurinic/apyrimidinic endonuclease 2 regulates the expansion of germinal centers by protecting against activation-induced cytidine deaminase-independent DNA damage in B cells.The DNA glycosylases Ogg1 and Nth1 do not contribute to Ig class switching in activated mouse splenic B cells.Mechanism and regulation of class switch recombinationA novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polymerase beta.p53 represses class switch recombination to IgG2a through its antioxidant functionNbs1 ChIP-Seq Identifies Off-Target DNA Double-Strand Breaks Induced by AID in Activated Splenic B Cells.Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.APE1- and APE2-dependent DNA breaks in immunoglobulin class switch recombination.Inducible DNA breaks in Ig S regions are dependent on AID and UNGClass switch recombination efficiency and junction microhomology patterns in Msh2-, Mlh1-, and Exo1-deficient mice depend on the presence of mu switch region tandem repeats.The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switchDNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.Mutations occur in the Ig Smu region but rarely in Sgamma regions prior to class switch recombination.AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected].Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.Mismatch repair converts AID-instigated nicks to double-strand breaks for antibody class-switch recombination.Response to Comment on “IgH Chain Class Switch Recombination: Mechanism and Regulation”The role of Apex2 in class-switch recombination of immunoglobulin genesDendritic cells support production of IgA and other non-IgM isotypes in clonal microculture
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description
hulumtuese
@sq
researcher
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wetenschapper
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հետազոտող
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name
Carol E. Schrader
@ast
Carol E. Schrader
@en
Carol E. Schrader
@es
Carol E. Schrader
@nl
Carol E. Schrader
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type
label
Carol E. Schrader
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Carol E. Schrader
@en
Carol E. Schrader
@es
Carol E. Schrader
@nl
Carol E. Schrader
@sl
prefLabel
Carol E. Schrader
@ast
Carol E. Schrader
@en
Carol E. Schrader
@es
Carol E. Schrader
@nl
Carol E. Schrader
@sl
P106
P1153
7006323155
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P31
P496
0000-0001-8920-6803