Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids.
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Voltage gated ion channel function: gating, conduction, and the role of water and protonsIn-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K+ Channels; Interaction and New TargetsFatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel FunctionRegulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.Membrane Electromechanics in Biology, with a Focus on Hearing.Resin-acid derivatives as potent electrostatic openers of voltage-gated K channels and suppressors of neuronal excitabilityElectrostatic tuning of cellular excitability.Dampening of hyperexcitability in CA1 pyramidal neurons by polyunsaturated fatty acids acting on voltage-gated ion channelsReduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly.Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channelElectronic polymers in lipid membranes.The Molecular Basis of Polyunsaturated Fatty Acid Interactions with the Shaker Voltage-Gated Potassium ChannelPIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker.A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels.The conserved phenylalanine in the K+ channel voltage-sensor domain creates a barrier with unidirectional effects.Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels.A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.Atomic determinants of BK channel activation by polyunsaturated fatty acids.Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels.Drug-induced ion channel opening tuned by the voltage sensor charge profile.Mechanism of electromechanical coupling in voltage-gated potassium channels.Isopimaric acid - a multi-targeting ion channel modulator reducing excitability and arrhythmicity in a spontaneously beating mouse atrial cell line.An electrostatic potassium channel opener targeting the final voltage sensor transition.Do lipids show state-dependent affinity to the voltage-gated potassium channel KvAP?Modulation of plant TPC channels by polyunsaturated fatty acids.Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively charged extracellular pore residuesEffects of a ketogenic diet on hippocampal plasticity in freely moving juvenile ratsA drug pocket at the lipid bilayer-potassium channel interface.Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel.Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).In silico Screening and Evaluation of the Anticonvulsant Activity of Docosahexaenoic Acid-Like Molecules in Experimental Models of SeizuresOxaliplatin neurotoxicity--no general ion channel surface-charge effect.Effects of unsaturated fatty acids on the kinetics of voltage-gated proton channels heterologously expressed in cultured cells.Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1).Regulation of Kv2.1 channel inactivation by phosphatidylinositol 4,5-bisphosphate.Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.Atom-by-atom tuning of the electrostatic potassium-channel modulator dehydroabietic acid.Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells.KCNE1 tunes the sensitivity of K7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site
P2860
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P2860
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids.
@en
type
label
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids.
@en
prefLabel
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids.
@en
P2860
P1433
P1476
Lipoelectric modification of ion channel voltage gating by polyunsaturated fatty acids.
@en
P2093
Sven Hammarström
P2860
P304
P356
10.1529/BIOPHYSJ.108.130757
P407
P577
2008-05-23T00:00:00Z