Small-molecule inhibitors of SETD8 with cellular activity.
about
Synthesis of lysine methyltransferase inhibitorsThe emerging role of lysine methyltransferase SETD8 in human diseasesCrystal structure-based discovery of a novel synthesized PARP1 inhibitor (OL-1) with apoptosis-inducing mechanisms in triple-negative breast cancer.Structure-activity relationship studies of SETD8 inhibitors.Selective inhibitors of protein methyltransferasesThe SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity.Inhibitors of Protein Methyltransferases and Demethylases.Loss of BAP1 function leads to EZH2-dependent transformation.Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compoundsProgress in the Development of Lysine Methyltransferase SETD8 Inhibitors.Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.Kinetic Analysis of PRMT1 Reveals Multifactorial Processivity and a Sequential Ordered Mechanism.Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy.BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
P2860
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P2860
Small-molecule inhibitors of SETD8 with cellular activity.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Small-molecule inhibitors of SETD8 with cellular activity.
@en
type
label
Small-molecule inhibitors of SETD8 with cellular activity.
@en
prefLabel
Small-molecule inhibitors of SETD8 with cellular activity.
@en
P2093
P2860
P356
P1433
P1476
Small-molecule inhibitors of SETD8 with cellular activity.
@en
P2093
Constantin Radu
David Shum
Glorymar Ibáñez
Hakim Djaballah
Judd C Rice
Minkui Luo
Xiangjun Rao
P2860
P304
P356
10.1021/CB500515R
P577
2014-09-03T00:00:00Z