Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.
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The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15The structural modifications induced by the M339F substitution in PBP2x from Streptococcus pneumoniae further decreases the susceptibility to beta-lactams of resistant strainsA PBP2x from a clinical isolate of Streptococcus pneumoniae exhibits an alternative mechanism for reduction of susceptibility to beta-lactam antibioticsX-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzymePenicillin-binding proteins and beta-lactam resistanceInteraction energies between beta-lactam antibiotics and E. coli penicillin-binding protein 5 by reversible thermal denaturationTranspeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan.Inhibition of Streptococcus pneumoniae penicillin-binding protein 2x and Actinomadura R39 DD-peptidase activities by ceftaroline.Identification of a structural determinant for resistance to beta-lactam antibiotics in Gram-positive bacteria.Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.Dual multimodular class A penicillin-binding proteins in Mycobacterium leprae.Molecular mechanisms of β-lactam resistance in Streptococcus pneumoniae.BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins.Identification and characterization of the penicillin-binding protein 2a of Streptococcus pneumoniae and its possible role in resistance to beta-lactam antibiotics.Novel scintillation proximity assay for measuring membrane-associated steps of peptidoglycan biosynthesis in Escherichia coli.Identification, purification, and characterization of transpeptidase and glycosyltransferase domains of Streptococcus pneumoniae penicillin-binding protein 1a.Biochemical characterization of penicillin-resistant and -sensitive penicillin-binding protein 2x transpeptidase activities of Streptococcus pneumoniae and mechanistic implications in bacterial resistance to beta-lactam antibiotics.The bimodular G57-V577 polypeptide chain of the class B penicillin-binding protein 3 of Escherichia coli catalyzes peptide bond formation from thiolesters and does not catalyze glycan chain polymerization from the lipid II intermediate.Interactions between penicillin-binding proteins (PBPs) and two novel classes of PBP inhibitors, arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones.Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance.Synthesis, purification and kinetic properties of fluorescein-labelled penicillins.Reaction of soluble penicillin-binding protein 2a of methicillin-resistant Staphylococcus aureus with beta-lactams and acyclic substrates: kinetics in homogeneous solution.The CiaRH system of Streptococcus pneumoniae prevents lysis during stress induced by treatment with cell wall inhibitors and by mutations in pbp2x involved in beta-lactam resistance.On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptidesBreakdown of the stereospecificity of DD-peptidases and beta-lactamases with thiolester substrates.Biochemical characterization of the 49 kDa penicillin-binding protein of Mycobacterium smegmatis.Hydrogen bonding and protein perturbation in beta-lactam acyl-enzymes of Streptococcus pneumoniae penicillin-binding protein PBP2x.Screen for inhibitors of the coupled transglycosylase-transpeptidase of peptidoglycan biosynthesis in Escherichia coli.Kinetics of beta-lactam interactions with penicillin-susceptible and -resistant penicillin-binding protein 2x proteins from Streptococcus pneumoniae. Involvement of acylation and deacylation in beta-lactam resistance.The kinetic properties of the carboxy terminal domain of the Bacillus licheniformis 749/I BlaR penicillin-receptor shed a new light on the derepression of beta-lactamase synthesis.Cure for a crisis?Increase of the deacylation rate of PBP2x from Streptococcus pneumoniae by single point mutations mimicking the class A beta-lactamases.Microplate assay for inhibitors of the transpeptidase activity of PBP1b of Escherichia coli.
P2860
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P2860
Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Penicillin-binding protein 2x ...... nteractions with beta-lactams.
@en
type
label
Penicillin-binding protein 2x ...... nteractions with beta-lactams.
@en
prefLabel
Penicillin-binding protein 2x ...... nteractions with beta-lactams.
@en
P2093
P2860
P356
P1433
P1476
Penicillin-binding protein 2x ...... nteractions with beta-lactams.
@en
P2093
P2860
P304
P356
10.1042/BJ2920735
P407
P478
292 ( Pt 3)
P577
1993-06-01T00:00:00Z