An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.
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The zinc cluster proteins Upc2 and Ecm22 promote filamentation in Saccharomyces cerevisiae by sterol biosynthesis-dependent and -independent pathways.The transcription factor Ndt80 does not contribute to Mrr1-, Tac1-, and Upc2-mediated fluconazole resistance in Candida albicansGlobal analysis of the evolution and mechanism of echinocandin resistance in Candida glabrataDiscovery of a HapE mutation that causes azole resistance in Aspergillus fumigatus through whole genome sequencing and sexual crossingA novel sterol regulatory element-binding protein gene (sreA) identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51) regulationResistance Mechanisms and Clinical Features of Fluconazole-Nonsusceptible Candida tropicalis Isolates Compared with Fluconazole-Less-Susceptible IsolatesUPC2 is universally essential for azole antifungal resistance in Candida albicans.UPC2A is required for high-level azole antifungal resistance in Candida glabrata.Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1.SREBP-dependent triazole susceptibility in Aspergillus fumigatus is mediated through direct transcriptional regulation of erg11A (cyp51A).Whole transcriptome analysis of Penicillium digitatum strains treatmented with prochloraz reveals their drug-resistant mechanismsGain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans.Milbemycins: more than efflux inhibitors for fungal pathogensCrystallization and preliminary X-ray crystallographic analysis of sterol transcription factor Upc2 from Saccharomyces cerevisiae.Comparison of sterol import under aerobic and anaerobic conditions in three fungal species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae.The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression.Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factorDistinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulenceAzole Antifungal Resistance in Candida albicans and Emerging Non-albicans Candida Species.Polymerase chain reaction-based assays for the diagnosis of invasive fungal infections.Medically important fungi respond to azole drugs: an update.Antifungals: Mechanism of Action and Drug Resistance.The development of fluconazole resistance in Candida albicans - an example of microevolution of a fungal pathogen.Fluconazole resistance in Candida species: a current perspective.From Lipid Homeostasis to Differentiation: Old and New Functions of the Zinc Cluster Proteins Ecm22, Upc2, Sut1 and Sut2.Competitive Fitness of Fluconazole-Resistant Clinical Candida albicans Strains.An acquired mechanism of antifungal drug resistance simultaneously enables Candida albicans to escape from intrinsic host defenses.Ascorbic acid inhibition of Candida albicans Hsp90-mediated morphogenesis occurs via the transcriptional regulator Upc2.Induction of Candida albicans drug resistance genes by hybrid zinc cluster transcription factors.In vitro and in vivo antifungal activities and mechanism of heteropolytungstates against Candida species.Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2.The Role of UPC2 Gene in Azole-Resistant Candida tropicalis.Loss of Upc2p-Inducible ERG3 Transcription Is Sufficient To Confer Niche-Specific Azole Resistance without Compromising Candida albicans Pathogenicity.
P2860
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P2860
An A643V amino acid substitution in Upc2p contributes to azole resistance in well-characterized clinical isolates of Candida albicans.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
An A643V amino acid substituti ...... isolates of Candida albicans.
@en
type
label
An A643V amino acid substituti ...... isolates of Candida albicans.
@en
prefLabel
An A643V amino acid substituti ...... isolates of Candida albicans.
@en
P2093
P2860
P356
P1476
An A643V amino acid substituti ...... l isolates of Candida albicans
@en
P2093
Adam R Smith
Ryan P Brown
Samantha J Hoot
P2860
P304
P356
10.1128/AAC.00995-10
P407
P577
2010-11-15T00:00:00Z