T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.
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A THEMIS:SHP1 complex promotes T-cell survivalTespa1 is involved in late thymocyte development through the regulation of TCR-mediated signalingInterchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular functionUbiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global ProfilingPhosphorylation site dynamics of early T-cell receptor signalingGRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.A proteomic view at T cell costimulationThemis2 is not required for B cell development, activation, and antibody responses.Fine-tuning T cell receptor signaling to control T cell developmentA spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease.THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge.Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response.Signaling in thymic selection.ERK positive feedback regulates a widespread network of tyrosine phosphorylation sites across canonical T cell signaling and actin cytoskeletal proteins in Jurkat T cells.THEMIS is required for pathogenesis of cerebral malaria and protection against pulmonary tuberculosis.Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes.Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation.Differential function of Themis CABIT domains during T cell developmentProtein networks and activation of lymphocytes.Genes related to inflammation and bone loss process in periodontitis suggested by bioinformatics methods.Increased THEMIS First Exon Usage in CD4+ T-Cells Is Associated with a Genotype that Is Protective against Multiple SclerosisIdentification of differentially expressed peptides in high-throughput proteomics data.Quantitative dynamics of phosphoproteome: the devil is in the details.A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in LymphocytesTespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes.Recent progress using systems biology approaches to better understand molecular mechanisms of immunity.Themis sets the signal threshold for positive and negative selection in T-cell developmentHolistic systems biology approaches to molecular mechanisms of human helper T cell differentiation to functionally distinct subsets.Exploring intercellular signaling by proteomic approaches.Integrative biology of T cell activation.Lighting Up T Lymphocyte Signaling with Quantitative Phosphoproteomics.THEMIS: Two Models, Different Thresholds.Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.TCR signalling network organization at the immunological synapses of murine regulatory T cells.TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.Molecular T cell biology -- basic and translational challenges in the twenty-first centurySynapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticlesA simple twist of phosphate: Immunological synapse formation and T cell receptor signaling outcome in regulatory T cells.Themis2 lowers the threshold for B cell activation during positive selection.
P2860
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P2860
T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
T cell receptor (TCR)-induced ...... new TCR signalosome component.
@en
type
label
T cell receptor (TCR)-induced ...... new TCR signalosome component.
@en
prefLabel
T cell receptor (TCR)-induced ...... new TCR signalosome component.
@en
P2093
P2860
P356
P1476
T cell receptor (TCR)-induced ...... new TCR signalosome component.
@en
P2093
Choon P Tan
Claudia Brockmeyer
David C Trudgian
David Pepper
Mogjiborahman Salek
Oreste Acuto
Simon McGowan
Wolfgang Paster
P2860
P304
P356
10.1074/JBC.M110.201236
P407
P577
2010-12-28T00:00:00Z