Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.
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SIRT1 as a therapeutic target in inflammaging of the pulmonary diseaseCellular senescence in normal and premature lung aging.A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICERAcrolein-exposed normal human lung fibroblasts in vitro: cellular senescence, enhanced telomere erosion, and degradation of Werner's syndrome proteinPulmonary artery smooth muscle cell senescence is a pathogenic mechanism for pulmonary hypertension in chronic lung disease.Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease.Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapyIdentification of an autophagy defect in smokers' alveolar macrophages.Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells.Cigarette smoke induces Akt protein degradation by the ubiquitin-proteasome systemImpaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary diseasePerspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence.Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damageWhole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility.Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines.APO-9'-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial CellsCigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner.Macrophage migration inhibitory factor deficiency in chronic obstructive pulmonary disease.Update in chronic obstructive pulmonary disease 2009.Cellular therapies for lung disease: a distant horizon.Knowledge translation: airway epithelial cell migration and respiratory diseases.Insulin-like growth factor binding proteins-3 and -5: central mediators of fibrosis and promising new therapeutic targets.Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPDOxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases.Construction of a computable network model for DNA damage, autophagy, cell death, and senescence.Soluble extracellular Klotho decreases sensitivity to cigarette smoke induced cell death in human lung epithelial cells.Interstitial Lung Disease in Werner Syndrome: A Case Report of a 55-Year-Old Male Patient.Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway.Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity.Fibroblasts that resist cigarette smoke-induced senescence acquire profibrotic phenotypes.Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema.Cigarette Smoke Induces Human Airway Epithelial Senescence via Growth Differentiation Factor 15 Production.Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema.
P2860
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P2860
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Cigarette smoke induces cellul ...... drome protein down-regulation.
@en
type
label
Cigarette smoke induces cellul ...... drome protein down-regulation.
@en
prefLabel
Cigarette smoke induces cellul ...... drome protein down-regulation.
@en
P2093
P2860
P50
P1476
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation
@en
P2093
Charles O Brown
Gary W Hunninghake
Heather Glaser
Jeffrey R Cagley
Junko Oshima
Martha M Monick
Nukhet Aykin-Burns
Toru Nyunoya
P2860
P304
P356
10.1164/RCCM.200802-320OC
P407
P577
2008-11-14T00:00:00Z