about
SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stressEssential Components of Cancer EducationMitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generationChitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lungLow-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and genderSusceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolismThe Absence of CpG in Plasmid DNA–Chitosan Polyplexes Enhances Transfection Efficiencies and Reduces Inflammatory Responses in Murine LungsMitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survivalPaclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress.Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathwaysRetroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like populationPolychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle.Acute toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) in male Sprague-Dawley rats: effects on hepatic oxidative stress, glutathione and metals status.Sirt3, mitochondrial ROS, ageing, and carcinogenesis.Reactive oxygen species in normal and tumor stem cells.Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesisKetogenic diets as an adjuvant cancer therapy: History and potential mechanismBreast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM.Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responsesAcetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress.Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancerLoss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma.Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism.Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4.Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway.Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart.Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma CellsBiobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma.Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acidIncreased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growthSimultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress.Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells.Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2).WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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name
Douglas R Spitz
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Douglas R Spitz
@en
Douglas R Spitz
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Douglas R Spitz
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type
label
Douglas R Spitz
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Douglas R Spitz
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Douglas R Spitz
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Douglas R Spitz
@nl
prefLabel
Douglas R Spitz
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Douglas R Spitz
@en
Douglas R Spitz
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Douglas R Spitz
@nl
P106
P1153
7006046019
P21
P31
P496
0000-0002-1254-8765