NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.
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SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathwayThe MST/Hippo Pathway and Cell Death: A Non-Canonical AffairNEDD4: a promising target for cancer therapyNedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis.The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway.Direct Exposure to Ethanol Disrupts Junctional Cell-Cell Contact and Hippo-YAP Signaling in HL-1 Murine Atrial Cardiomyocytes.p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase ItchDUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT ProteinsHippo-YAP signaling pathway: A new paradigm for cancer therapy.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Genome-wide analysis of the WW domain-containing protein genes in silkworm and their expansion in eukaryotes.Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability.NEDD4 is involved in acquisition of epithelial-mesenchymal transition in cisplatin-resistant nasopharyngeal carcinoma cells.Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network.The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress.Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.Inhibition of NEDD4 inhibits cell growth and invasion and induces cell apoptosis in bladder cancer cells.Regulation of the Hippo Signaling Pathway by Ubiquitin Modification.NEDD4 promotes cell growth and motility in hepatocellular carcinoma.Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer.
P2860
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P2860
NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
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2013年论文
@zh-cn
name
NEDD4 E3 ligase inhibits the a ...... rgeting LATS1 for degradation.
@en
type
label
NEDD4 E3 ligase inhibits the a ...... rgeting LATS1 for degradation.
@en
prefLabel
NEDD4 E3 ligase inhibits the a ...... rgeting LATS1 for degradation.
@en
P2093
P2860
P356
P1433
P1476
NEDD4 E3 ligase inhibits the a ...... rgeting LATS1 for degradation.
@en
P2093
Ella Itzhaki
Rami I Aqeilan
Sherri Cohen
Zaidoun Salah
P2860
P304
P356
10.4161/CC.26672
P577
2013-10-07T00:00:00Z