AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.
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The Evolution of Epigenetics: From Prokaryotes to Humans and Its Biological ConsequencesReprogramming DNA methylation in the mammalian life cycle: building and breaking epigenetic barriersMechanism and function of oxidative reversal of DNA and RNA methylationEtoposide induces nuclear re-localisation of AIDRole of TET enzymes in DNA methylation, development, and cancerRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites5-Hydroxymethylcytosine: generation, fate, and genomic distributionProcessive DNA demethylation via DNA deaminase-induced lesion resolutionA germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformationNon-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylomeTET enzymes, TDG and the dynamics of DNA demethylation.Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitroRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase.Mapping recently identified nucleotide variants in the genome and transcriptome.Mechanisms of epigenetic memory and addiction.AID enzymatic activity is inversely proportional to the size of cytosine C5 orbital cloud.Epigenetic regulation of pluripotency and differentiationThe AID-induced DNA damage response in chromatin.Single-base resolution analysis of active DNA demethylation using methylase-assisted bisulfite sequencing.No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos.Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase.The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neuronsDifferential programming of B cells in AID deficient miceDetection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling.TET proteins and the control of cytosine demethylation in cancer.Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin.Non-coding RNA Generated following Lariat Debranching Mediates Targeting of AID to DNAStella preserves maternal chromosome integrity by inhibiting 5hmC-induced γH2AX accumulation.Catalytic analysis of APOBEC3G involving real-time NMR spectroscopy reveals nucleic acid determinants for deamination.Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine.Muscle cell identity requires Pax7-mediated lineage-specific DNA demethylationDNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B.Crosstalk Between DNA and Histones: Tet's New Role in Embryonic Stem Cells.Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA DemethylationNucleic acid modifications with epigenetic significance.APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication.A critical role for AID in the initiation of reprogramming to induced pluripotent stem cellsDNA methylation in schizophrenia: progress and challenges of epigenetic studiesWeakened N3 Hydrogen Bonding by 5-Formylcytosine and 5-Carboxylcytosine Reduces Their Base-Pairing Stability
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AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.
@en
type
label
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.
@en
prefLabel
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation.
@en
P2093
P2860
P50
P356
P1476
AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
@en
P2093
Christopher S Nabel
James T Stivers
P2860
P2888
P304
P356
10.1038/NCHEMBIO.1042
P577
2012-07-08T00:00:00Z