Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species
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Pulmonary oxidative stress, inflammation and cancer: respirable particulate matter, fibrous dusts and ozone as major causes of lung carcinogenesis through reactive oxygen species mechanismsSperm DNA oxidative damage and DNA adductsFormation and Biological Targets of Quinones: Cytotoxic versus Cytoprotective EffectsHuman aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbonsInterception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cellsThe Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-QuinonesDetoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTs) in human lung cellsOxidative stress and air pollution exposureDetoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catecholsAryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dioneFjord-region benzo[g]chrysene-11,12-dihydrodiol and benzo[c]phenanthrene-3,4-dihydrodiol as substrates for rat liver dihydrodiol dehydrogenase (AKR1C9): structural basis for stereochemical preferenceOn the formation and properties of interstrand DNA-DNA cross-links forged by reaction of an abasic site with the opposing guanine residue of 5'-CAp sequences in duplex DNA.Chromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.Phototoxicity and environmental transformation of polycyclic aromatic hydrocarbons (PAHs)-light-induced reactive oxygen species, lipid peroxidation, and DNA damage.Ozone co-exposure modifies cardiac responses to fine and ultrafine ambient particulate matter in mice: concordance of electrocardiogram and mechanical responsesHuman aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms.Genotoxicity in Atlantic killifish (Fundulus heteroclitus) from a PAH-contaminated Superfund site on the Elizabeth River, Virginia.Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.Modular, Metal-Catalyzed Cycloisomerization Approach to Angularly Fused Polycyclic Aromatic Hydrocarbons and Their Oxidized Derivatives.Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection.Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites.Effects of Fine Particulate Matter (PM2.5) on Systemic Oxidative Stress and Cardiac Function in ApoE(-/-) Mice.Genotoxicity of poorly soluble particles.Light-Induced Toxic Effects of Tamoxifen: A Chemotherapeutic and Chemopreventive AgentOxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.Lesion processing: high-fidelity versus lesion-bypass DNA polymerasesThe pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance.Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation.The role of base excision repair genes OGG1, APN1 and APN2 in benzo[a]pyrene-7,8-dione induced p53 mutagenesis.Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress.Protective effects of lemongrass essential oil against benzo(a)pyrene-induced oxidative stress and DNA damage in human embryonic lung fibroblast cells.p53 Mutagenesis by benzo[a]pyrene derived radical cations.Real-time detection of Fe.EDTA/H2O2-induced DNA cleavage by linear dichroism.Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification.
P2860
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P2860
Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Polycyclic aromatic hydrocarbo ...... uo via reactive oxygen species
@en
type
label
Polycyclic aromatic hydrocarbo ...... uo via reactive oxygen species
@en
prefLabel
Polycyclic aromatic hydrocarbo ...... uo via reactive oxygen species
@en
P2860
P356
P1476
Polycyclic aromatic hydrocarbo ...... uo via reactive oxygen species
@en
P2093
Jong-Heum Park
Ronald G Harvey
P2860
P304
P356
10.1021/TX0600245
P577
2006-05-01T00:00:00Z