Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
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Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes4(1H)-pyridone and 4(1H)-quinolone derivatives as antimalarials with erythrocytic, exoerythrocytic, and transmission blocking activitiesStructure-based design of novel small-molecule inhibitors of Plasmodium falciparum.Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers.Subnanomolar inhibitor of cytochrome bc1 complex designed by optimizing interaction with conformationally flexible residuesQuinolone-3-diarylethers: a new class of antimalarial drug.Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparumA chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitorSynthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii.Metal-free arylation of ethyl acetoacetate with hypervalent diaryliodonium salts: an immediate access to diverse 3-aryl-4(1H)-quinolones.Tyrosine triad at the interface between the Rieske iron-sulfur protein, cytochrome c1 and cytochrome c2 in the bc1 complex of Rhodobacter capsulatus.Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malariaNew paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections.The global portfolio of new antimalarial medicines under development.Small molecule anti-malarial patents: a review (January 2010-June 2011).Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria.Targeting the mitochondrial electron transport chain of Plasmodium falciparum: new strategies towards the development of improved antimalarials for the elimination era.Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance.Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl)-1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate.Synthesis, characterization, and antimicrobial evaluation of novel 5-benzoyl-N-substituted amino- and 5-benzoyl-N-sulfonylamino-4-alkylsulfanyl-2-pyridones.Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.Atom-Economic Synthesis of 4-Pyrones from Diynones and Water.Isoxazole mediated synthesis of 4-(1H)pyridones: improved preparation of antimalarial candidate GSK932121.Functional screening of selective mitochondrial inhibitors of PlasmodiumRecent updates in the discovery and development of novel antimalarial drug candidatesThe development of quinoloneesters as novel antimalarial agents targeting the Plasmodium falciparum bc1protein complex
P2860
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P2860
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
@en
type
label
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
@en
prefLabel
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
@en
P2093
P356
P1476
Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.
@en
P2093
Alan T Hudson
Clive L Yeates
Domingo Gargallo-Viola
Edward C Capon
Esperanza Herreros
Esther Fernández
Federico Gómez de las Heras
Helen Trimming
James Woolven
Jesús Chicharro
P304
P356
10.1021/JM0705760
P407
P577
2008-04-09T00:00:00Z