A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
about
Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drugGlobal phenotypic screening for antimalarialsApplication of genomics to field investigations of malaria by the international centers of excellence for malaria researchRecent advances in malaria drug discoveryUsing genetic methods to define the targets of compounds with antimalarial activityAntimalarial drug discovery - approaches and progress towards new medicines.Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone AntimalarialsImaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug DiscoveryMuddled mechanisms: recent progress towards antimalarial target identificationMitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen familiesReconstructing the Qo site of Plasmodium falciparum bc 1 complex in the yeast enzymeUtilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas DiseaseParasites resistant to the antimalarial atovaquone fail to transmit by mosquitoesLong-Term Prophylaxis and Pharmacokinetic Evaluation of Intramuscular Nano- and Microparticle Decoquinate in Mice Infected with P. berghei Sporozoites.A Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors.Emergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reportsSelective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporinSystems-level antimicrobial drug and drug synergy discovery.Progressing the global antimalarial portfolio: finding drugs which target multiple Plasmodium life stages.In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.Dihydroquinazolinone inhibitors of proliferation of blood and liver stage malaria parasitesDiversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.Antiparasitic chemotherapy: from genomes to mechanisms.Saccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.Discovery of Dual-Stage Malaria Inhibitors with New Targets.Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.Formulation and particle size reduction improve bioavailability of poorly water-soluble compounds with antimalarial activity.Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins.Metabolomic Profiling of the Malaria Box Reveals Antimalarial Target Pathways.Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.Harnessing genomics and genome biology to understand malaria biology.Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.Novel inhibitors of the Plasmodium falciparum electron transport chain.From crystal to compound: structure-based antimalarial drug discovery.Atovaquone tolerance in Plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth.
P2860
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P2860
A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
A chemical genomic analysis of ...... ciparum cytochrome b inhibitor
@ast
A chemical genomic analysis of ...... ciparum cytochrome b inhibitor
@en
type
label
A chemical genomic analysis of ...... ciparum cytochrome b inhibitor
@ast
A chemical genomic analysis of ...... ciparum cytochrome b inhibitor
@en
prefLabel
A chemical genomic analysis of ...... ciparum cytochrome b inhibitor
@ast
A chemical genomic analysis of ...... ciparum cytochrome b inhibitor
@en
P2093
P2860
P50
P356
P1433
P1476
A chemical genomic analysis of ...... ciparum cytochrome b inhibitor
@en
P2093
Akhil B Vaidya
Badry Bursulaya
Case W McNamara
David M Plouffe
Hangjun Ke
Nobutaka Kato
Peter G Schultz
Selina Bopp
Susan McCormack
Tae-Gyu Nam
P2860
P304
P356
10.1021/CB200105D
P577
2011-09-08T00:00:00Z