The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2.
about
Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysisDisplacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin BStefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleftS46 Peptidases are the First Exopeptidases to be Members of Clan PAStructural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity.Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probesNeutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defensesLeukocyte cathepsin C deficiency attenuates atherosclerotic lesion progression by selective tuning of innate and adaptive immune responses.Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets.Inhibitors of cathepsin C (dipeptidyl peptidase I).The regulatory role of Dipeptidyl peptidase I on the activation of immune granulocytes.Inherited diseases caused by mutations in cathepsin protease genes.Discovery of novel cyanamide-based inhibitors of cathepsin C.Development and validation of a simple cell-based fluorescence assay for dipeptidyl peptidase 1 (DPP1) activity.Evidence for a founder mutation in the cathepsin C gene in three families with Papillon-Lefèvre syndromeE-64c-hydrazide: a lead structure for the development of irreversible cathepsin C inhibitors.Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite.Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
P2860
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P2860
The crystal structure of human dipeptidyl peptidase I (cathepsin C) in complex with the inhibitor Gly-Phe-CHN2.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
The crystal structure of human ...... th the inhibitor Gly-Phe-CHN2.
@en
type
label
The crystal structure of human ...... th the inhibitor Gly-Phe-CHN2.
@en
prefLabel
The crystal structure of human ...... th the inhibitor Gly-Phe-CHN2.
@en
P2093
P2860
P356
P1433
P1476
The crystal structure of human ...... th the inhibitor Gly-Phe-CHN2.
@en
P2093
Anne Mølgaard
Conni Lauritzen
Gitte Petersen
John Pedersen
Jose Arnau
P2860
P304
P356
10.1042/BJ20061389
P407
P50
P577
2007-02-01T00:00:00Z