Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex.
about
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNAHuman AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sitesThymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sitesRepair of oxidative DNA damage and cancer: recent progress in DNA base excision repairNon-productive DNA damage binding by DNA glycosylase-like protein Mag2 from Schizosaccharomyces pombeThe structural basis of XRCC1-mediated DNA repairRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesVersatile recombinant SUMOylation system for the production of SUMO-modified proteinDependence of substrate binding and catalysis on pH, ionic strength, and temperature for thymine DNA glycosylase: Insights into recognition and processing of G·T mispairsA network of enzymes involved in repair of oxidative DNA damage in Neisseria meningitidisThymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNABase excision repair of tandem modifications in a methylated CpG dinucleotide.Chemical shift assignments for human apurinic/apyrimidinic endonuclease 1.AP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site ProductE2-mediated small ubiquitin-like modifier (SUMO) modification of thymine DNA glycosylase is efficient but not selective for the enzyme-product complex.Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screenNonspecific DNA binding and coordination of the first two steps of base excision repair.Recent advances in the structural mechanisms of DNA glycosylasesPoly(ADP-ribosyl)ation acts in the DNA demethylation of mouse primordial germ cells also with DNA damage-independent roles.The hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repairStoichiometry and affinity for thymine DNA glycosylase binding to specific and nonspecific DNAEffect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.SIRT6 protein deacetylase interacts with MYH DNA glycosylase, APE1 endonuclease, and Rad9-Rad1-Hus1 checkpoint clampHistone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.Defining the functional footprint for recognition and repair of deaminated DNA7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.3CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair.Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in VivoCoordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.Transient-state kinetics of apurinic/apyrimidinic (AP) endonuclease 1 acting on an authentic AP site and commonly used substrate analogs: the effect of diverse metal ions and base mismatches.Epigenetic reprogramming: is deamination key to active DNA demethylation?Role of two strictly conserved residues in nucleotide flipping and N-glycosylic bond cleavage by human thymine DNA glycosylase.Divergent mechanisms for enzymatic excision of 5-formylcytosine and 5-carboxylcytosine from DNA.Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.Interaction of apurinic/apyrimidinic endonuclease 2 (Apn2) with Myh1 DNA glycosylase in fission yeast5-methylcytosine recognition by Arabidopsis thaliana DNA glycosylases DEMETER and DML3Recognition of damaged DNA: structure and dynamic markers.Small-molecule inhibitors of DNA damage-repair pathways: an approach to overcome tumor resistance to alkylating anticancer drugs.Two-way communications between ubiquitin-like modifiers and DNA.
P2860
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P2860
Coordinating the initial steps of base excision repair. Apurinic/apyrimidinic endonuclease 1 actively stimulates thymine DNA glycosylase by disrupting the product complex.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Coordinating the initial steps ...... isrupting the product complex.
@en
type
label
Coordinating the initial steps ...... isrupting the product complex.
@en
prefLabel
Coordinating the initial steps ...... isrupting the product complex.
@en
P2860
P356
P1476
Coordinating the initial steps ...... isrupting the product complex.
@en
P2093
Alexander C Drohat
Megan E Fitzgerald
P2860
P304
32680-32690
P356
10.1074/JBC.M805504200
P407
P577
2008-09-19T00:00:00Z