hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup
about
SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repairMutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylaseEarly steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsHuman APOBEC3G can restrict retroviral infection in avian cells and acts independently of both UNG and SMUG1Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanismsProduction of infectious human immunodeficiency virus type 1 does not require depletion of APOBEC3G from virus-producing cellsLack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsCancer Evolution-Development: experience of hepatitis B virus-induced hepatocarcinogenesisDNA glycosylases: in DNA repair and beyondBase excision repair and cancerStructure of uracil-DNAN-glycosylase (UNG) fromVibrio cholerae: mapping temperature adaptation through structural and mutational analysisStructural Characterization of a Mouse Ortholog of Human NEIL3 with a Marked Preference for Single-Stranded DNAStructure of the uracil complex ofVaccinia virusuracil DNA glycosylaseBase excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracilSubstrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activityThe main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosineDifferential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutationMolecular characterization of Plasmodium falciparum uracil-DNA glycosylase and its potential as a new anti-malarial drug targetBCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.Mutational analysis of arginine 276 in the leucine-loop of human uracil-DNA glycosylase.Mimicking damaged DNA with a small molecule inhibitor of human UNG2.Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine.Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.Rotational dynamics of DNA on the nucleosome surface markedly impact accessibility to a DNA repair enzyme.Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.Viral RNA is required for the association of APOBEC3G with human immunodeficiency virus type 1 nucleoprotein complexes.Deleterious Effects of Chronic Folate Deficiency in the Ts65Dn Mouse Model of Down Syndrome.C --> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylasesAP-Endonuclease 1 Accelerates Turnover of Human 8-Oxoguanine DNA Glycosylase by Preventing Retrograde Binding to the Abasic-Site ProductDirect interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.MicroRNA binding site polymorphisms as biomarkers in cancer management and research.Human base excision repair creates a bias toward -1 frameshift mutationsCheckpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.Uracil DNA glycosylase is dispensable for human immunodeficiency virus type 1 replication and does not contribute to the antiviral effects of the cytidine deaminase Apobec3G.Recent advances in the structural mechanisms of DNA glycosylasesIntrinsic apurinic/apyrimidinic (AP) endonuclease activity enables Bacillus subtilis DNA polymerase X to recognize, incise, and further repair abasic sites.Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins.B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.
P2860
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P2860
hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
hUNG2 is the major repair enzy ...... as a broad specificity backup
@ast
hUNG2 is the major repair enzy ...... as a broad specificity backup
@en
hUNG2 is the major repair enzy ...... as a broad specificity backup
@en-gb
hUNG2 is the major repair enzy ...... as a broad specificity backup
@nl
type
label
hUNG2 is the major repair enzy ...... as a broad specificity backup
@ast
hUNG2 is the major repair enzy ...... as a broad specificity backup
@en
hUNG2 is the major repair enzy ...... as a broad specificity backup
@en-gb
hUNG2 is the major repair enzy ...... as a broad specificity backup
@nl
prefLabel
hUNG2 is the major repair enzy ...... as a broad specificity backup
@ast
hUNG2 is the major repair enzy ...... as a broad specificity backup
@en
hUNG2 is the major repair enzy ...... as a broad specificity backup
@en-gb
hUNG2 is the major repair enzy ...... as a broad specificity backup
@nl
P2093
P50
P356
P1476
hUNG2 is the major repair enzy ...... as a broad specificity backup
@en
P2093
Bodil Kavli
Lars Hagen
Ottar Sundheim
Per Arne Aas
P304
P356
10.1074/JBC.M207107200
P407
P577
2002-10-18T00:00:00Z