A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling. - Wikidata - wikimedia - TriplyDB

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.

http://www.wikidata.org/entity/Q41953486

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LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons An emerging role for prdm family genes in dorsoventral patterning of the vertebrate nervous system Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation Genome-wide expression analysis of Ptf1a- and Ascl1-deficient mice reveals new markers for distinct dorsal horn interneuron populations contributing to nociceptive reflex plasticity Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity Ptf1a is expressed transiently in all types of amacrine cells in the embryonic zebrafish retina.Origin and determination of inhibitory cell lineages in the vertebrate retina Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth's short tail mice.Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells.Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system The transcription factor RBP-J is essential for retinal cell differentiation and lamination.Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function Mash1-dependent Notch Signaling Pathway Regulates GABAergic Neuron-Like Differentiation from Bone Marrow-Derived Mesenchymal Stem Cells.Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development.Characterization of genetically targeted neuron types in the zebrafish optic tectum.Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer.A transcription factor network specifying inhibitory versus excitatory neurons in the dorsal spinal cord.A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse.Loss of the Notch effector RBPJ promotes tumorigenesis.Not(ch) just development: Notch signalling in the adult brain.Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.The role of Notch receptors in transcriptional regulation Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development GABAergic neuron specification in the spinal cord, the cerebellum, and the cochlear nucleus.Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting.Uncovering stem cell differentiation factors for salivary gland regeneration by quantitative analysis of differential proteomes Fast synaptic inhibition in spinal sensory processing and pain control.Loss of Ptf1a Leads to a Widespread Cell-Fate Misspecification in the Brainstem, Affecting the Development of Somatosensory and Viscerosensory Nuclei.Early pancreatic islet fate and maturation is controlled through RBP-Jκ RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation.Program specificity for Ptf1a in pancreas versus neural tube development correlates with distinct collaborating cofactors and chromatin accessibility.Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window.Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome

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P2860

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling.

http://www.wikidata.org/entity/Q41953486

description

2008 nî lūn-bûn

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name

A nonclassical bHLH Rbpj trans ...... ndependent of Notch signaling.

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type

label

A nonclassical bHLH Rbpj trans ...... ndependent of Notch signaling.

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prefLabel

A nonclassical bHLH Rbpj trans ...... ndependent of Notch signaling.

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A nonclassical bHLH Rbpj trans ...... ndependent of Notch signaling.

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Benedetta Martarelli

http://www.w3.org/2001/XMLSchema#string

Carmen Birchmeier

http://www.w3.org/2001/XMLSchema#string

Hendrik Wildner

http://www.w3.org/2001/XMLSchema#string

Jonathan A Epstein

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Justyna Cholewa-Waclaw

http://www.w3.org/2001/XMLSchema#string

Kei Hori

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R Michael Henke

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Raymond J Macdonald

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Stacey M Glasgow

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Thomas M Beres

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P2860

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

Mutations in PTF1A cause pancreatic and cerebellar agenesis

PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L.

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms

The p48 DNA-binding subunit of transcription factor PTF1 is a new exocrine pancreas-specific basic helix-loop-helix protein

The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas

A histone deacetylase corepressor complex regulates the Notch signal transduction pathway

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells

Generalized lacZ expression with the ROSA26 Cre reporter strain

Radial glial identity is promoted by Notch1 signaling in the murine forebrain

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10.1101/GAD.1628008

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2

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22

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5653874

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18198335

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2192752

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