MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
about
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery.Properties and applications of single-chain major histocompatibility complex class I molecules.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.The structural basis of chicken, swine and bovine CD8αα dimers provides insight into the co-evolution with MHC I in endotherm species.CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.The molecular determinants of CD8 co-receptor function.Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy.TCR gene transfer: MAGE-C2/HLA-A2 and MAGE-A3/HLA-DP4 epitopes as melanoma-specific immune targets.CD8 controls T cell cross-reactivity.IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cellsProximity of TCR and its CD8 coreceptor controls sensitivity of T cells.Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function.
P2860
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P2860
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
MHC class I molecules with Sup ...... nonspecifically activate CTLs.
@en
type
label
MHC class I molecules with Sup ...... nonspecifically activate CTLs.
@en
prefLabel
MHC class I molecules with Sup ...... nonspecifically activate CTLs.
@en
P2093
P2860
P50
P356
P1476
MHC class I molecules with Sup ...... nonspecifically activate CTLs
@en
P2093
Anna Lissina
Bruno Laugel
Cor Berrevoets
Emma Gostick
Julia Ekeruche
Linda Wooldridge
Mathew Clement
Reno Debets
P2860
P304
P356
10.4049/JIMMUNOL.0902398
P407
P50
P577
2010-02-26T00:00:00Z