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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

http://www.wikidata.org/entity/Q41962064

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Redox signaling regulated by electrophiles and reactive sulfur species The Nrf2/HO-1 Axis in Cancer Cell Growth and Chemoresistance Pharmacology and Clinical Drug Candidates in Redox Medicine Roles nrf2 plays in myeloid cells and related disorders Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO Nrf2 mediates redox adaptations to exercise Nrf2 Is an Attractive Therapeutic Target for Retinal Diseases Mechanisms of Nrf2/Keap1-dependent phase II cytoprotective and detoxifying gene expression and potential cellular targets of chemopreventive isothiocyanates Schisandra chinensis regulates drug metabolizing enzymes and drug transporters via activation of Nrf2-mediated signaling pathway A generalizable platform for interrogating target- and signal-specific consequences of electrophilic modifications in redox-dependent cell signaling The complexity of the Nrf2 pathway: beyond the antioxidant response Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease The clinical potential of influencing Nrf2 signaling in degenerative and immunological disorders Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism Frequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.Role of Nuclear Factor Erythroid 2-Related Factor 2 in Diabetic Nephropathy.Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene.Visualization of the Drosophila dKeap1-CncC interaction on chromatin illumines cooperative, xenobiotic-specific gene activation.Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.Protective Effects of L-Malate against Myocardial Ischemia/Reperfusion Injury in Rats Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation.Cell signaling pathways involved in drug-mediated fetal hemoglobin induction: Strategies to treat sickle cell disease Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response Antioxidant capacity of phytochemicals and their potential effects on oxidative status in animals - A review.Modification of cysteine residues by cyclopentenone prostaglandins: interplay with redox regulation of protein function.Pathophysiology of tobacco smoke exposure: recent insights from comparative and redox proteomics.Role of the Nrf2 signaling system in health and disease.Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time.Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate.TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1.Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.HX-1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression.Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.Fibroblast growth factor 21 and its novel association with oxidative stress.

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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

http://www.wikidata.org/entity/Q41962064

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

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type

label

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

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prefLabel

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

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J.FREERADBIOMED.2012.06.023

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Free Radical Biology and Medicine

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Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

@en

P2093

Hozumi Motohashi

http://www.w3.org/2001/XMLSchema#string

Kai Takaya

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Ko Onodera

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Masayuki Yamamoto

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Susumu Satomi

http://www.w3.org/2001/XMLSchema#string

Takafumi Suzuki

http://www.w3.org/2001/XMLSchema#string

Thomas W Kensler

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P2860

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection

Ebselen, a seleno-organic antioxidant, as an electrophile

The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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817-827

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scholarly article

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10.1016/J.FREERADBIOMED.2012.06.023

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4

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2012-06-23T00:00:00Z

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22732183

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3539416

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